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Anti-PDC6I/ PDCD6IP/ AIP1 functional antibody
Anti-PDC6I/ PDCD6IP/ AIP1 functional antibody for cell culture, ELISA & in-vivo assay
Go to PDCD6IP/PDCD6IP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1594-Ab-1/ GM-Tg-hg-SE1594-Ab-2 | Anti-Human PDCD6IP monoclonal antibody | Human |
| GM-Tg-rg-SE1594-Ab-1/ GM-Tg-rg-SE1594-Ab-2 | Anti-Rat PDCD6IP monoclonal antibody | Rat |
| GM-Tg-mg-SE1594-Ab-1/ GM-Tg-mg-SE1594-Ab-2 | Anti-Mouse PDCD6IP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1594-Ab-1/ GM-Tg-cynog-SE1594-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDCD6IP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1594-Ab-1/ GM-Tg-felg-SE1594-Ab-2 | Anti-Feline PDCD6IP monoclonal antibody | Feline |
| GM-Tg-cang-SE1594-Ab-1/ GM-Tg-cang-SE1594-Ab-2 | Anti-Canine PDCD6IP monoclonal antibody | Canine |
| GM-Tg-bovg-SE1594-Ab-1/ GM-Tg-bovg-SE1594-Ab-2 | Anti-Bovine PDCD6IP monoclonal antibody | Bovine |
| GM-Tg-equg-SE1594-Ab-1/ GM-Tg-equg-SE1594-Ab-2 | Anti-Equine PDCD6IP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1594-Ab-1/ GM-Tg-hg-SE1594-Ab-2; GM-Tg-rg-SE1594-Ab-1/ GM-Tg-rg-SE1594-Ab-2; GM-Tg-mg-SE1594-Ab-1/ GM-Tg-mg-SE1594-Ab-2; GM-Tg-cynog-SE1594-Ab-1/ GM-Tg-cynog-SE1594-Ab-2; GM-Tg-felg-SE1594-Ab-1/ GM-Tg-felg-SE1594-Ab-2; GM-Tg-cang-SE1594-Ab-1/ GM-Tg-cang-SE1594-Ab-2; GM-Tg-bovg-SE1594-Ab-1/ GM-Tg-bovg-SE1594-Ab-2; GM-Tg-equg-SE1594-Ab-1/ GM-Tg-equg-SE1594-Ab-2 |
| Products Name | Anti-PDCD6IP monoclonal antibody |
| Format | mab |
| Target Name | PDCD6IP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDCD6IP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1594-Ag-1 | Recombinant multi-species PDC6I/ PDCD6IP/ AIP1 protein |
Target information
| Target ID | GM-SE1594 |
| Target Name | PDCD6IP |
| Gene ID | 10015,18571,501083,706636,477015,101095279,533406,100050741 |
| Gene Symbol and Synonyms | AIP1,ALIX,DRIP4,Eig2,HP95,MCPH29,mKIAA1375,PDCD6IP,RGD1561176 |
| Uniprot Accession | Q8WUM4,Q9QZA2 |
| Uniprot Entry Name | PDC6I_HUMAN,PDC6I_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000170248 |
| Target Classification | N/A |
The target: PDCD6IP, gene name: PDCD6IP, also named as AIP1, ALIX, DRIP4, HP95. This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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