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Anti-RNH1/ RNASEH1/ H1RNA functional antibody
Anti-RNH1/ RNASEH1/ H1RNA functional antibody for cell culture, ELISA & in-vivo assay
Go to RNASEH1/RNASEH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1599-Ab-1/ GM-Tg-hg-SE1599-Ab-2 | Anti-Human RNASEH1 monoclonal antibody | Human |
| GM-Tg-rg-SE1599-Ab-1/ GM-Tg-rg-SE1599-Ab-2 | Anti-Rat RNASEH1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1599-Ab-1/ GM-Tg-mg-SE1599-Ab-2 | Anti-Mouse RNASEH1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1599-Ab-1/ GM-Tg-cynog-SE1599-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RNASEH1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1599-Ab-1/ GM-Tg-felg-SE1599-Ab-2 | Anti-Feline RNASEH1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1599-Ab-1/ GM-Tg-cang-SE1599-Ab-2 | Anti-Canine RNASEH1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1599-Ab-1/ GM-Tg-bovg-SE1599-Ab-2 | Anti-Bovine RNASEH1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1599-Ab-1/ GM-Tg-equg-SE1599-Ab-2 | Anti-Equine RNASEH1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1599-Ab-1/ GM-Tg-hg-SE1599-Ab-2; GM-Tg-rg-SE1599-Ab-1/ GM-Tg-rg-SE1599-Ab-2; GM-Tg-mg-SE1599-Ab-1/ GM-Tg-mg-SE1599-Ab-2; GM-Tg-cynog-SE1599-Ab-1/ GM-Tg-cynog-SE1599-Ab-2; GM-Tg-felg-SE1599-Ab-1/ GM-Tg-felg-SE1599-Ab-2; GM-Tg-cang-SE1599-Ab-1/ GM-Tg-cang-SE1599-Ab-2; GM-Tg-bovg-SE1599-Ab-1/ GM-Tg-bovg-SE1599-Ab-2; GM-Tg-equg-SE1599-Ab-1/ GM-Tg-equg-SE1599-Ab-2 |
| Products Name | Anti-RNASEH1 monoclonal antibody |
| Format | mab |
| Target Name | RNASEH1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RNASEH1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1599-Ag-1 | Recombinant multi-species RNH1/ RNASEH1/ H1RNA protein |
| ORF Viral Vector | vGMLP002657 | human RNASEH1 Lentivirus particle |
| ORF Viral Vector | pGMLP002657 | human RNASEH1 Lentivirus plasmid |
Target information
| Target ID | GM-SE1599 |
| Target Name | RNASEH1 |
| Gene ID | 246243,19819,298933,707122,475648,101097476,613354,100072832 |
| Gene Symbol and Synonyms | H1RNA,PEOB2,RNASEH1,RNH1 |
| Uniprot Accession | O60930,Q5BK46 |
| Uniprot Entry Name | RNH1_HUMAN,RNH1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000171865 |
| Target Classification | N/A |
The target: RNASEH1, gene name: RNASEH1, also named as H1RNA, PEOB2, RNH1. This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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