Anti-PDIA1/ P4HB/ CLCRP1 functional antibody

Anti-PDIA1/ P4HB/ CLCRP1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to P4HB/P4HB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1636-Ab-1/ GM-Tg-hg-SE1636-Ab-2Anti-Human P4HB monoclonal antibodyHuman
GM-Tg-rg-SE1636-Ab-1/ GM-Tg-rg-SE1636-Ab-2Anti-Rat P4HB monoclonal antibodyRat
GM-Tg-mg-SE1636-Ab-1/ GM-Tg-mg-SE1636-Ab-2Anti-Mouse P4HB monoclonal antibodyMouse
GM-Tg-cynog-SE1636-Ab-1/ GM-Tg-cynog-SE1636-Ab-2Anti-Cynomolgus/ Rhesus macaque P4HB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1636-Ab-1/ GM-Tg-felg-SE1636-Ab-2Anti-Feline P4HB monoclonal antibodyFeline
GM-Tg-cang-SE1636-Ab-1/ GM-Tg-cang-SE1636-Ab-2Anti-Canine P4HB monoclonal antibodyCanine
GM-Tg-bovg-SE1636-Ab-1/ GM-Tg-bovg-SE1636-Ab-2Anti-Bovine P4HB monoclonal antibodyBovine
GM-Tg-equg-SE1636-Ab-1/ GM-Tg-equg-SE1636-Ab-2Anti-Equine P4HB monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1636-Ab-1/ GM-Tg-hg-SE1636-Ab-2; GM-Tg-rg-SE1636-Ab-1/ GM-Tg-rg-SE1636-Ab-2;
GM-Tg-mg-SE1636-Ab-1/ GM-Tg-mg-SE1636-Ab-2; GM-Tg-cynog-SE1636-Ab-1/ GM-Tg-cynog-SE1636-Ab-2;
GM-Tg-felg-SE1636-Ab-1/ GM-Tg-felg-SE1636-Ab-2; GM-Tg-cang-SE1636-Ab-1/ GM-Tg-cang-SE1636-Ab-2;
GM-Tg-bovg-SE1636-Ab-1/ GM-Tg-bovg-SE1636-Ab-2; GM-Tg-equg-SE1636-Ab-1/ GM-Tg-equg-SE1636-Ab-2
Products NameAnti-P4HB monoclonal antibody
Formatmab
Target NameP4HB
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-P4HB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1636-Ag-1Recombinant multi-species PDIA1/ P4HB/ CLCRP1 protein
    ORF Viral VectorvGMLP002953human P4HB Lentivirus particle
    ORF Viral VectorpGMLP002953human P4HB Lentivirus plasmid
    ORF Viral VectorpGMLPm002712mouse P4hb Lentivirus plasmid
    ORF Viral VectorvGMLPm002712mouse P4hb Lentivirus particle


    Target information

    Target IDGM-SE1636
    Target NameP4HB
    Gene ID5034,18453,25506,714702,483369,101099917,281373,100055188
    Gene Symbol and SynonymsCLCRP1,DSI,ERBA2L,ERp59,GIT,P4HB,P4Hbeta,PDI,PDIA1,PDIR,PHDB,PO4DB,PO4HB,PROHB,Thbp
    Uniprot AccessionP07237,P04785,P05307
    Uniprot Entry NamePDIA1_HUMAN,PDIA1_RAT,PDIA1_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseContrast - Induced Nephropathy
    Gene EnsemblENSG00000185624
    Target ClassificationN/A

    The target: P4HB, gene name: P4HB, also named as CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB. This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.