Anti-PDIA1/ P4HB/ CLCRP1 functional antibody
Anti-PDIA1/ P4HB/ CLCRP1 functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-SE1636-Ab-1/ GM-Tg-hg-SE1636-Ab-2 | Anti-Human P4HB monoclonal antibody | Human |
GM-Tg-rg-SE1636-Ab-1/ GM-Tg-rg-SE1636-Ab-2 | Anti-Rat P4HB monoclonal antibody | Rat |
GM-Tg-mg-SE1636-Ab-1/ GM-Tg-mg-SE1636-Ab-2 | Anti-Mouse P4HB monoclonal antibody | Mouse |
GM-Tg-cynog-SE1636-Ab-1/ GM-Tg-cynog-SE1636-Ab-2 | Anti-Cynomolgus/ Rhesus macaque P4HB monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-SE1636-Ab-1/ GM-Tg-felg-SE1636-Ab-2 | Anti-Feline P4HB monoclonal antibody | Feline |
GM-Tg-cang-SE1636-Ab-1/ GM-Tg-cang-SE1636-Ab-2 | Anti-Canine P4HB monoclonal antibody | Canine |
GM-Tg-bovg-SE1636-Ab-1/ GM-Tg-bovg-SE1636-Ab-2 | Anti-Bovine P4HB monoclonal antibody | Bovine |
GM-Tg-equg-SE1636-Ab-1/ GM-Tg-equg-SE1636-Ab-2 | Anti-Equine P4HB monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-SE1636-Ab-1/ GM-Tg-hg-SE1636-Ab-2; GM-Tg-rg-SE1636-Ab-1/ GM-Tg-rg-SE1636-Ab-2; GM-Tg-mg-SE1636-Ab-1/ GM-Tg-mg-SE1636-Ab-2; GM-Tg-cynog-SE1636-Ab-1/ GM-Tg-cynog-SE1636-Ab-2; GM-Tg-felg-SE1636-Ab-1/ GM-Tg-felg-SE1636-Ab-2; GM-Tg-cang-SE1636-Ab-1/ GM-Tg-cang-SE1636-Ab-2; GM-Tg-bovg-SE1636-Ab-1/ GM-Tg-bovg-SE1636-Ab-2; GM-Tg-equg-SE1636-Ab-1/ GM-Tg-equg-SE1636-Ab-2 |
Products Name | Anti-P4HB monoclonal antibody |
Format | mab |
Target Name | P4HB |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-P4HB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-SE1636-Ag-1 | Recombinant multi-species PDIA1/ P4HB/ CLCRP1 protein |
ORF Viral Vector | vGMLP002953 | human P4HB Lentivirus particle |
ORF Viral Vector | pGMLP002953 | human P4HB Lentivirus plasmid |
ORF Viral Vector | pGMLPm002712 | mouse P4hb Lentivirus plasmid |
ORF Viral Vector | vGMLPm002712 | mouse P4hb Lentivirus particle |
Target information
Target ID | GM-SE1636 |
Target Name | P4HB |
Gene ID | 5034,18453,25506,714702,483369,101099917,281373,100055188 |
Gene Symbol and Synonyms | CLCRP1,DSI,ERBA2L,ERp59,GIT,P4HB,P4Hbeta,PDI,PDIA1,PDIR,PHDB,PO4DB,PO4HB,PROHB,Thbp |
Uniprot Accession | P07237,P04785,P05307 |
Uniprot Entry Name | PDIA1_HUMAN,PDIA1_RAT,PDIA1_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | |
Disease | Contrast - Induced Nephropathy |
Gene Ensembl | ENSG00000185624 |
Target Classification | N/A |
The target: P4HB, gene name: P4HB, also named as CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB. This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.