Anti-CL3L1/ CCL3L1/ D17S1718 functional antibody

Anti-CL3L1/ CCL3L1/ D17S1718 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CCL3L1/CCL3L1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1673-Ab-1/ GM-Tg-hg-SE1673-Ab-2Anti-Human CCL3L1 monoclonal antibodyHuman
GM-Tg-rg-SE1673-Ab-1/ GM-Tg-rg-SE1673-Ab-2Anti-Rat CCL3L1 monoclonal antibodyRat
GM-Tg-mg-SE1673-Ab-1/ GM-Tg-mg-SE1673-Ab-2Anti-Mouse CCL3L1 monoclonal antibodyMouse
GM-Tg-cynog-SE1673-Ab-1/ GM-Tg-cynog-SE1673-Ab-2Anti-Cynomolgus/ Rhesus macaque CCL3L1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1673-Ab-1/ GM-Tg-felg-SE1673-Ab-2Anti-Feline CCL3L1 monoclonal antibodyFeline
GM-Tg-cang-SE1673-Ab-1/ GM-Tg-cang-SE1673-Ab-2Anti-Canine CCL3L1 monoclonal antibodyCanine
GM-Tg-bovg-SE1673-Ab-1/ GM-Tg-bovg-SE1673-Ab-2Anti-Bovine CCL3L1 monoclonal antibodyBovine
GM-Tg-equg-SE1673-Ab-1/ GM-Tg-equg-SE1673-Ab-2Anti-Equine CCL3L1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1673-Ab-1/ GM-Tg-hg-SE1673-Ab-2; GM-Tg-rg-SE1673-Ab-1/ GM-Tg-rg-SE1673-Ab-2;
GM-Tg-mg-SE1673-Ab-1/ GM-Tg-mg-SE1673-Ab-2; GM-Tg-cynog-SE1673-Ab-1/ GM-Tg-cynog-SE1673-Ab-2;
GM-Tg-felg-SE1673-Ab-1/ GM-Tg-felg-SE1673-Ab-2; GM-Tg-cang-SE1673-Ab-1/ GM-Tg-cang-SE1673-Ab-2;
GM-Tg-bovg-SE1673-Ab-1/ GM-Tg-bovg-SE1673-Ab-2; GM-Tg-equg-SE1673-Ab-1/ GM-Tg-equg-SE1673-Ab-2
Products NameAnti-CCL3L1 monoclonal antibody
Formatmab
Target NameCCL3L1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCL3L1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1673-Ag-1Recombinant multi-species CL3L1/ CCL3L1/ D17S1718 protein
    ORF Viral VectorpGMLP000966human CCL3L1 Lentivirus plasmid
    ORF Viral VectorvGMLP000966human CCL3L1 Lentivirus particle


    Target information

    Target IDGM-SE1673
    Target NameCCL3L1
    Gene ID6349
    Gene Symbol and Synonyms464.2,CCL3L1,D17S1718,G0S19-2,LD78,LD78-beta(1-70),LD78BETA,MIP1AP,SCYA3L,SCYA3L1
    Uniprot AccessionP16619
    Uniprot Entry NameCL3L1_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000277796
    Target ClassificationN/A

    The target: CCL3L1, gene name: CCL3L1, also named as 464.2, D17S1718, G0S19-2, LD78, LD78-beta(1-70), LD78BETA, MIP1AP, SCYA3L, SCYA3L1. This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.