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Anti-MK/ Midkine/ MDK functional antibody
Anti-MK/ Midkine/ MDK functional antibody for cell culture, ELISA & in-vivo assay
Go to Midkine/MDK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T03878-Ab-1/ GM-Tg-hg-T03878-Ab-2 | Anti-Human Midkine/MDK monoclonal antibody | Human |
| GM-Tg-rg-T03878-Ab-1/ GM-Tg-rg-T03878-Ab-2 | Anti-Rat Midkine/MDK monoclonal antibody | Rat |
| GM-Tg-mg-T03878-Ab-1/ GM-Tg-mg-T03878-Ab-2 | Anti-Mouse Midkine/MDK monoclonal antibody | Mouse |
| GM-Tg-cynog-T03878-Ab-1/ GM-Tg-cynog-T03878-Ab-2 | Anti-Cynomolgus/ Rhesus macaque Midkine/MDK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T03878-Ab-1/ GM-Tg-felg-T03878-Ab-2 | Anti-Feline Midkine/MDK monoclonal antibody | Feline |
| GM-Tg-cang-T03878-Ab-1/ GM-Tg-cang-T03878-Ab-2 | Anti-Canine Midkine/MDK monoclonal antibody | Canine |
| GM-Tg-bovg-T03878-Ab-1/ GM-Tg-bovg-T03878-Ab-2 | Anti-Bovine Midkine/MDK monoclonal antibody | Bovine |
| GM-Tg-equg-T03878-Ab-1/ GM-Tg-equg-T03878-Ab-2 | Anti-Equine Midkine/MDK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T03878-Ab-1/ GM-Tg-hg-T03878-Ab-2; GM-Tg-rg-T03878-Ab-1/ GM-Tg-rg-T03878-Ab-2; GM-Tg-mg-T03878-Ab-1/ GM-Tg-mg-T03878-Ab-2; GM-Tg-cynog-T03878-Ab-1/ GM-Tg-cynog-T03878-Ab-2; GM-Tg-felg-T03878-Ab-1/ GM-Tg-felg-T03878-Ab-2; GM-Tg-cang-T03878-Ab-1/ GM-Tg-cang-T03878-Ab-2; GM-Tg-bovg-T03878-Ab-1/ GM-Tg-bovg-T03878-Ab-2; GM-Tg-equg-T03878-Ab-1/ GM-Tg-equg-T03878-Ab-2 |
| Products Name | Anti-Midkine/MDK monoclonal antibody |
| Format | mab |
| Target Name | Midkine |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-Midkine benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T03878-Ag-1 | Recombinant multi-species MK/ Midkine/ MDK protein |
| ORF Viral Vector | vGMLP000499 | human MDK Lentivirus particle |
| ORF Viral Vector | vGMAP000446 | Human MDK Adenovirus particle |
| ORF Viral Vector | pGMAP000446 | Human MDK Adenovirus plasmid |
| ORF Viral Vector | pGMLP000499 | human MDK Lentivirus plasmid |
| ORF Viral Vector | pGMAP000465 | Human MDK Adenovirus plasmid |
| ORF Viral Vector | vGMAP000465 | Human MDK Adenovirus particle |
| ORF Viral Vector | pGMLPm000134 | mouse Mdk Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000134 | mouse Mdk Lentivirus particle |
Target information
| Target ID | GM-T03878 |
| Target Name | Midkine |
| Gene ID | 4192,17242,81517,714591,119864230,101087941,280852,100147284 |
| Gene Symbol and Synonyms | ARAP,MDK,Mek,MK,NEGF2 |
| Uniprot Accession | P21741,Q9R1S9 |
| Uniprot Entry Name | MK_HUMAN,MK_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Lung Cancer, Malignant neoplasm of bladder, Urinary bladder urothelial carcinoma, breast cancer |
| Gene Ensembl | ENSG00000110492 |
| Target Classification | N/A |
The target: Midkine, gene name: MDK, also named as ARAP, MK, NEGF2. This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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