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Anti-ANO1/ ANO/ DOG1 monoclonal antibody
Anti-ANO1/ ANO/ DOG1 antibody for FACS & in-vivo assay
Go to ANO/ANO1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T05089-Ab-1/ GM-Tg-hg-T05089-Ab-2 | Anti-Human ANO/ANO1 monoclonal antibody | Human |
| GM-Tg-rg-T05089-Ab-1/ GM-Tg-rg-T05089-Ab-2 | Anti-Rat ANO/ANO1 monoclonal antibody | Rat |
| GM-Tg-mg-T05089-Ab-1/ GM-Tg-mg-T05089-Ab-2 | Anti-Mouse ANO/ANO1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T05089-Ab-1/ GM-Tg-cynog-T05089-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ANO/ANO1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T05089-Ab-1/ GM-Tg-felg-T05089-Ab-2 | Anti-Feline ANO/ANO1 monoclonal antibody | Feline |
| GM-Tg-cang-T05089-Ab-1/ GM-Tg-cang-T05089-Ab-2 | Anti-Canine ANO/ANO1 monoclonal antibody | Canine |
| GM-Tg-bovg-T05089-Ab-1/ GM-Tg-bovg-T05089-Ab-2 | Anti-Bovine ANO/ANO1 monoclonal antibody | Bovine |
| GM-Tg-equg-T05089-Ab-1/ GM-Tg-equg-T05089-Ab-2 | Anti-Equine ANO/ANO1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T05089-Ab-1/ GM-Tg-hg-T05089-Ab-2; GM-Tg-rg-T05089-Ab-1/ GM-Tg-rg-T05089-Ab-2; GM-Tg-mg-T05089-Ab-1/ GM-Tg-mg-T05089-Ab-2; GM-Tg-cynog-T05089-Ab-1/ GM-Tg-cynog-T05089-Ab-2; GM-Tg-felg-T05089-Ab-1/ GM-Tg-felg-T05089-Ab-2; GM-Tg-cang-T05089-Ab-1/ GM-Tg-cang-T05089-Ab-2; GM-Tg-bovg-T05089-Ab-1/ GM-Tg-bovg-T05089-Ab-2; GM-Tg-equg-T05089-Ab-1/ GM-Tg-equg-T05089-Ab-2 |
| Products Name | Anti-ANO/ANO1 monoclonal antibody |
| Format | mab |
| Target Name | ANO |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ANO benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ANO1/ ANO/ DOG1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002834 | human ANO1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002834 | human ANO1 Lentivirus particle |
| ORF Viral Vector | pGMLV000700 | zebrafish ano1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000700 | zebrafish ano1 Lentivirus particle |
Target information
| Target ID | GM-T05089 |
| Target Name | ANO |
| Gene ID | 55107,101772,309135,708723,611698,101087608,532126,100061836 |
| Gene Symbol and Synonyms | ANO1,DOG1,INDMS,ORAOV2,TAOS2,™EM16A |
| Uniprot Accession | Q5XXA6 |
| Uniprot Entry Name | ANO1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000131620 |
| Target Classification | N/A |
The target: ANO, gene name: ANO1, also named as DOG1, ORAOV2, TAOS2, ™EM16A. Enables calcium activated cation channel activity; intracellular calcium activated chloride channel activity; and iodide transmembrane transporter activity. Involved in cation transport; inorganic anion transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in apical plasma membrane and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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