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Anti-IL18/ IGIF/ IL-18 functional antibody
Anti-IL18/ IGIF/ IL-18 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL18/IL18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T06671-Ab-1/ GM-Tg-hg-T06671-Ab-2 | Anti-Human IL18 monoclonal antibody | Human |
| GM-Tg-rg-T06671-Ab-1/ GM-Tg-rg-T06671-Ab-2 | Anti-Rat IL18 monoclonal antibody | Rat |
| GM-Tg-mg-T06671-Ab-1/ GM-Tg-mg-T06671-Ab-2 | Anti-Mouse IL18 monoclonal antibody | Mouse |
| GM-Tg-cynog-T06671-Ab-1/ GM-Tg-cynog-T06671-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL18 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T06671-Ab-1/ GM-Tg-felg-T06671-Ab-2 | Anti-Feline IL18 monoclonal antibody | Feline |
| GM-Tg-cang-T06671-Ab-1/ GM-Tg-cang-T06671-Ab-2 | Anti-Canine IL18 monoclonal antibody | Canine |
| GM-Tg-bovg-T06671-Ab-1/ GM-Tg-bovg-T06671-Ab-2 | Anti-Bovine IL18 monoclonal antibody | Bovine |
| GM-Tg-equg-T06671-Ab-1/ GM-Tg-equg-T06671-Ab-2 | Anti-Equine IL18 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T06671-Ab-1/ GM-Tg-hg-T06671-Ab-2; GM-Tg-rg-T06671-Ab-1/ GM-Tg-rg-T06671-Ab-2; GM-Tg-mg-T06671-Ab-1/ GM-Tg-mg-T06671-Ab-2; GM-Tg-cynog-T06671-Ab-1/ GM-Tg-cynog-T06671-Ab-2; GM-Tg-felg-T06671-Ab-1/ GM-Tg-felg-T06671-Ab-2; GM-Tg-cang-T06671-Ab-1/ GM-Tg-cang-T06671-Ab-2; GM-Tg-bovg-T06671-Ab-1/ GM-Tg-bovg-T06671-Ab-2; GM-Tg-equg-T06671-Ab-1/ GM-Tg-equg-T06671-Ab-2 |
| Products Name | Anti-IL18 monoclonal antibody |
| Format | mab |
| Target Name | IL18 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL18 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T06671-Ag-1 | Recombinant multi-species IL18/ IGIF/ IL-18 protein |
| Cytokine | GM-Tg-g-T06671-Ag-1 | interleukin 18 (IL18) protein |
| ORF Viral Vector | pGMLP002771 | human IL18 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002771 | human IL18 Lentivirus particle |
| ORF Viral Vector | pGMLPm000116 | mouse Il18 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005397 | mouse Il18 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000116 | mouse Il18 Lentivirus particle |
| ORF Viral Vector | vGMLPm005397 | mouse Il18 Lentivirus particle |
Target information
| Target ID | GM-T06671 |
| Target Name | IL18 |
| Gene ID | 3606,16173,29197,574151,403796,493688,281249,100034216 |
| Gene Symbol and Synonyms | IGIF,IL-1 gamma,IL-18,IL-1g,IL18,IL1F4 |
| Uniprot Accession | Q14116,P97636,Q9XSR0,Q95M33,Q9TU73,Q9XSQ7 |
| Uniprot Entry Name | IL18_HUMAN,IL18_RAT,IL18_FELCA,IL18_CANLF,IL18_BOVIN,IL18_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Breast Cancer, Acute kidney failure, Overweight |
| Gene Ensembl | ENSG00000150782 |
| Target Classification | N/A |
The target: IL18, gene name: IL18, also named as IGIF, IL-18, IL-1g, IL1F4. The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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