Anti-PACA/ PACAP-38/ ADCYAP1 functional antibody
Anti-PACA/ PACAP-38/ ADCYAP1 functional antibody for cell culture, ELISA & in-vivo assay
Go to PACAP-38/ADCYAP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T07045-Ab-1/ GM-Tg-hg-T07045-Ab-2 | Anti-Human PACAP-38/ADCYAP1 monoclonal antibody | Human |
GM-Tg-rg-T07045-Ab-1/ GM-Tg-rg-T07045-Ab-2 | Anti-Rat PACAP-38/ADCYAP1 monoclonal antibody | Rat |
GM-Tg-mg-T07045-Ab-1/ GM-Tg-mg-T07045-Ab-2 | Anti-Mouse PACAP-38/ADCYAP1 monoclonal antibody | Mouse |
GM-Tg-cynog-T07045-Ab-1/ GM-Tg-cynog-T07045-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PACAP-38/ADCYAP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T07045-Ab-1/ GM-Tg-felg-T07045-Ab-2 | Anti-Feline PACAP-38/ADCYAP1 monoclonal antibody | Feline |
GM-Tg-cang-T07045-Ab-1/ GM-Tg-cang-T07045-Ab-2 | Anti-Canine PACAP-38/ADCYAP1 monoclonal antibody | Canine |
GM-Tg-bovg-T07045-Ab-1/ GM-Tg-bovg-T07045-Ab-2 | Anti-Bovine PACAP-38/ADCYAP1 monoclonal antibody | Bovine |
GM-Tg-equg-T07045-Ab-1/ GM-Tg-equg-T07045-Ab-2 | Anti-Equine PACAP-38/ADCYAP1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T07045-Ab-1/ GM-Tg-hg-T07045-Ab-2; GM-Tg-rg-T07045-Ab-1/ GM-Tg-rg-T07045-Ab-2; GM-Tg-mg-T07045-Ab-1/ GM-Tg-mg-T07045-Ab-2; GM-Tg-cynog-T07045-Ab-1/ GM-Tg-cynog-T07045-Ab-2; GM-Tg-felg-T07045-Ab-1/ GM-Tg-felg-T07045-Ab-2; GM-Tg-cang-T07045-Ab-1/ GM-Tg-cang-T07045-Ab-2; GM-Tg-bovg-T07045-Ab-1/ GM-Tg-bovg-T07045-Ab-2; GM-Tg-equg-T07045-Ab-1/ GM-Tg-equg-T07045-Ab-2 |
Products Name | Anti-PACAP-38/ADCYAP1 monoclonal antibody |
Format | mab |
Target Name | PACAP-38 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-PACAP-38 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T07045-Ag-1 | Recombinant multi-species PACA/ PACAP-38/ ADCYAP1 protein |
ORF Viral Vector | pGMLP004453 | human Adcyap1 Lentivirus plasmid |
ORF Viral Vector | vGMLP004453 | human Adcyap1 Lentivirus particle |
ORF Viral Vector | pGMAAV000317 | human ADCYAP1 AAV plasmid |
ORF Viral Vector | vGMAAV000317 | human ADCYAP1 AAV particle |
ORF Viral Vector | pGMAAV000069 | rat Adcyap1 AAV plasmid |
ORF Viral Vector | pGMLPm001128 | mouse Adcyap1 Lentivirus plasmid |
ORF Viral Vector | vGMAAV000069 | rat Adcyap1 AAV particle |
ORF Viral Vector | vGMLPm001128 | mouse Adcyap1 Lentivirus particle |
Target information
Target ID | GM-T07045 |
Target Name | PACAP-38 |
Gene ID | 116,11516,24166,100424113,607433,101090471,615187,100061356 |
Gene Symbol and Synonyms | ADCYAP1,PACAP |
Uniprot Accession | P18509,P13589,Q29W19 |
Uniprot Entry Name | PACA_HUMAN,PACA_RAT,PACA_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000141433 |
Target Classification | Tumor-associated antigen (TAA) |
The target: PACAP-38, gene name: ADCYAP1, also named as PACAP. This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.