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Anti-MRP1/ ABCC1/ ABC29 monoclonal antibody
Anti-MRP1/ ABCC1/ ABC29 antibody for FACS & in-vivo assay
Go to ABCC1/ABCC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T11288-Ab-1/ GM-Tg-hg-T11288-Ab-2 | Anti-Human ABCC1 monoclonal antibody | Human |
| GM-Tg-rg-T11288-Ab-1/ GM-Tg-rg-T11288-Ab-2 | Anti-Rat ABCC1 monoclonal antibody | Rat |
| GM-Tg-mg-T11288-Ab-1/ GM-Tg-mg-T11288-Ab-2 | Anti-Mouse ABCC1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T11288-Ab-1/ GM-Tg-cynog-T11288-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ABCC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T11288-Ab-1/ GM-Tg-felg-T11288-Ab-2 | Anti-Feline ABCC1 monoclonal antibody | Feline |
| GM-Tg-cang-T11288-Ab-1/ GM-Tg-cang-T11288-Ab-2 | Anti-Canine ABCC1 monoclonal antibody | Canine |
| GM-Tg-bovg-T11288-Ab-1/ GM-Tg-bovg-T11288-Ab-2 | Anti-Bovine ABCC1 monoclonal antibody | Bovine |
| GM-Tg-equg-T11288-Ab-1/ GM-Tg-equg-T11288-Ab-2 | Anti-Equine ABCC1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T11288-Ab-1/ GM-Tg-hg-T11288-Ab-2; GM-Tg-rg-T11288-Ab-1/ GM-Tg-rg-T11288-Ab-2; GM-Tg-mg-T11288-Ab-1/ GM-Tg-mg-T11288-Ab-2; GM-Tg-cynog-T11288-Ab-1/ GM-Tg-cynog-T11288-Ab-2; GM-Tg-felg-T11288-Ab-1/ GM-Tg-felg-T11288-Ab-2; GM-Tg-cang-T11288-Ab-1/ GM-Tg-cang-T11288-Ab-2; GM-Tg-bovg-T11288-Ab-1/ GM-Tg-bovg-T11288-Ab-2; GM-Tg-equg-T11288-Ab-1/ GM-Tg-equg-T11288-Ab-2 |
| Products Name | Anti-ABCC1 monoclonal antibody |
| Format | mab |
| Target Name | ABCC1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ABCC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MRP1/ ABCC1/ ABC29 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T11288 |
| Target Name | ABCC1 |
| Gene ID | 4363,17250,24565,717857,403453,101101279,281588,791240 |
| Gene Symbol and Synonyms | ABC29,ABCC,ABCC1,Abcc1a,Abcc1b,Avcc1a,DFNA77,GS-X,Mdrap,MRP,MRP1 |
| Uniprot Accession | P33527,Q8CG09,Q6UR05,Q8HXQ5 |
| Uniprot Entry Name | MRP1_HUMAN,MRP1_RAT,MRP1_CANLF,MRP1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000103222 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ABCC1, gene name: ABCC1, also named as ABC29, ABCC, GS-X, MRP, MRP1. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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