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Anti-PTPN11 monoclonal antibody
Pre-made anti-PTPN11 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PTPN11/PTPN11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T13057-Ab-1/ GM-Tg-hg-T13057-Ab-2 | Anti-Human PTPN11 monoclonal antibody | Human |
| GM-Tg-rg-T13057-Ab-1/ GM-Tg-rg-T13057-Ab-2 | Anti-Rat PTPN11 monoclonal antibody | Rat |
| GM-Tg-mg-T13057-Ab-1/ GM-Tg-mg-T13057-Ab-2 | Anti-Mouse PTPN11 monoclonal antibody | Mouse |
| GM-Tg-cynog-T13057-Ab-1/ GM-Tg-cynog-T13057-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPN11 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T13057-Ab-1/ GM-Tg-felg-T13057-Ab-2 | Anti-Feline PTPN11 monoclonal antibody | Feline |
| GM-Tg-cang-T13057-Ab-1/ GM-Tg-cang-T13057-Ab-2 | Anti-Canine PTPN11 monoclonal antibody | Canine |
| GM-Tg-bovg-T13057-Ab-1/ GM-Tg-bovg-T13057-Ab-2 | Anti-Bovine PTPN11 monoclonal antibody | Bovine |
| GM-Tg-equg-T13057-Ab-1/ GM-Tg-equg-T13057-Ab-2 | Anti-Equine PTPN11 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T13057-Ab-1/ GM-Tg-hg-T13057-Ab-2; GM-Tg-rg-T13057-Ab-1/ GM-Tg-rg-T13057-Ab-2; GM-Tg-mg-T13057-Ab-1/ GM-Tg-mg-T13057-Ab-2; GM-Tg-cynog-T13057-Ab-1/ GM-Tg-cynog-T13057-Ab-2; GM-Tg-felg-T13057-Ab-1/ GM-Tg-felg-T13057-Ab-2; GM-Tg-cang-T13057-Ab-1/ GM-Tg-cang-T13057-Ab-2; GM-Tg-bovg-T13057-Ab-1/ GM-Tg-bovg-T13057-Ab-2; GM-Tg-equg-T13057-Ab-1/ GM-Tg-equg-T13057-Ab-2 |
| Products Name | Anti-PTPN11 monoclonal antibody |
| Format | mab |
| Target Name | PTPN11 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PTPN11 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T13057-Ag-1 | Recombinant multi-species PTN11/ PTPN11/ BPTP3 protein |
| ORF Viral Vector | pGMAD000149 | human PTPN11 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000276 | human PTPN11 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000276 | human PTPN11 Lentivirus particle |
| ORF Viral Vector | vGMAD000149 | human PTPN11 Adenovirus particle |
| ORF Viral Vector | pGMLV000403 | mouse Ptpn11 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000403 | mouse Ptpn11 Lentivirus particle |
Target information
| Target ID | GM-T13057 |
| Target Name | PTPN11 |
| Gene ID | 5781,19247,25622,712044,477488,101085500,533590,100056857 |
| Gene Symbol and Synonyms | 2700084A17Rik,BPTP3,CFC,JMML,METCDS,NS1,PTP-1D,PTP1D,PTP2C,PTPN11,SAP-2,SH-PTP2,SH-PTP3,SHP-2,SHP2,Syp |
| Uniprot Accession | Q06124,P41499 |
| Uniprot Entry Name | PTN11_HUMAN,PTN11_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000179295 |
| Target Classification | N/A |
The target: PTPN11, gene name: PTPN11, also named as BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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