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Anti-CYP19A1 monoclonal antibody
Pre-made anti-CYP19A1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CYP19A1/CYP19A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T13260-Ab-1/ GM-Tg-hg-T13260-Ab-2 | Anti-Human CYP19A1 monoclonal antibody | Human |
| GM-Tg-rg-T13260-Ab-1/ GM-Tg-rg-T13260-Ab-2 | Anti-Rat CYP19A1 monoclonal antibody | Rat |
| GM-Tg-mg-T13260-Ab-1/ GM-Tg-mg-T13260-Ab-2 | Anti-Mouse CYP19A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T13260-Ab-1/ GM-Tg-cynog-T13260-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYP19A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T13260-Ab-1/ GM-Tg-felg-T13260-Ab-2 | Anti-Feline CYP19A1 monoclonal antibody | Feline |
| GM-Tg-cang-T13260-Ab-1/ GM-Tg-cang-T13260-Ab-2 | Anti-Canine CYP19A1 monoclonal antibody | Canine |
| GM-Tg-bovg-T13260-Ab-1/ GM-Tg-bovg-T13260-Ab-2 | Anti-Bovine CYP19A1 monoclonal antibody | Bovine |
| GM-Tg-equg-T13260-Ab-1/ GM-Tg-equg-T13260-Ab-2 | Anti-Equine CYP19A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T13260-Ab-1/ GM-Tg-hg-T13260-Ab-2; GM-Tg-rg-T13260-Ab-1/ GM-Tg-rg-T13260-Ab-2; GM-Tg-mg-T13260-Ab-1/ GM-Tg-mg-T13260-Ab-2; GM-Tg-cynog-T13260-Ab-1/ GM-Tg-cynog-T13260-Ab-2; GM-Tg-felg-T13260-Ab-1/ GM-Tg-felg-T13260-Ab-2; GM-Tg-cang-T13260-Ab-1/ GM-Tg-cang-T13260-Ab-2; GM-Tg-bovg-T13260-Ab-1/ GM-Tg-bovg-T13260-Ab-2; GM-Tg-equg-T13260-Ab-1/ GM-Tg-equg-T13260-Ab-2 |
| Products Name | Anti-CYP19A1 monoclonal antibody |
| Format | mab |
| Target Name | CYP19A1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CYP19A1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T13260-Ag-1 | Recombinant multi-species CP19A/ CYP19A1/ ARO protein |
| ORF Viral Vector | pGMLV000457 | human CYP19A1 Lentivirus plasmid |
| ORF Viral Vector | pGMAP000276 | Human CYP19A1 Adenovirus plasmid |
| ORF Viral Vector | vGMLV000457 | human CYP19A1 Lentivirus particle |
| ORF Viral Vector | vGMAP000276 | Human CYP19A1 Adenovirus particle |
| ORF Viral Vector | pGMLPm003021 | mouse Cyp19a1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003021 | mouse Cyp19a1 Lentivirus particle |
Target information
| Target ID | GM-T13260 |
| Target Name | CYP19A1 |
| Gene ID | 1588,13075,25147,678697,494003,101094932,281740,100009712 |
| Gene Symbol and Synonyms | Ar,ArKO,ARO,ARO1,Aromatase,CPV1,CYAR,CYP19,Cyp19a,CYP19A1,CYP19P1,CYPXIX,Int-5,Int5,P-450AROM,p450arom |
| Uniprot Accession | P11511,P22443,Q5QQX7,P46194,O46512 |
| Uniprot Entry Name | CP19A_HUMAN,CP19A_RAT,CP19A_CANLF,CP19A_BOVIN,CP19A_HORSE |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Breast cancer |
| Gene Ensembl | ENSG00000137869 |
| Target Classification | N/A |
The target: CYP19A1, gene name: CYP19A1, also named as ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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