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Anti-SIRT1 monoclonal antibody
Pre-made anti-SIRT1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SIRT1/SIRT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T14731-Ab-1/ GM-Tg-hg-T14731-Ab-2 | Anti-Human SIRT1 monoclonal antibody | Human |
| GM-Tg-rg-T14731-Ab-1/ GM-Tg-rg-T14731-Ab-2 | Anti-Rat SIRT1 monoclonal antibody | Rat |
| GM-Tg-mg-T14731-Ab-1/ GM-Tg-mg-T14731-Ab-2 | Anti-Mouse SIRT1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T14731-Ab-1/ GM-Tg-cynog-T14731-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SIRT1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T14731-Ab-1/ GM-Tg-felg-T14731-Ab-2 | Anti-Feline SIRT1 monoclonal antibody | Feline |
| GM-Tg-cang-T14731-Ab-1/ GM-Tg-cang-T14731-Ab-2 | Anti-Canine SIRT1 monoclonal antibody | Canine |
| GM-Tg-bovg-T14731-Ab-1/ GM-Tg-bovg-T14731-Ab-2 | Anti-Bovine SIRT1 monoclonal antibody | Bovine |
| GM-Tg-equg-T14731-Ab-1/ GM-Tg-equg-T14731-Ab-2 | Anti-Equine SIRT1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T14731-Ab-1/ GM-Tg-hg-T14731-Ab-2; GM-Tg-rg-T14731-Ab-1/ GM-Tg-rg-T14731-Ab-2; GM-Tg-mg-T14731-Ab-1/ GM-Tg-mg-T14731-Ab-2; GM-Tg-cynog-T14731-Ab-1/ GM-Tg-cynog-T14731-Ab-2; GM-Tg-felg-T14731-Ab-1/ GM-Tg-felg-T14731-Ab-2; GM-Tg-cang-T14731-Ab-1/ GM-Tg-cang-T14731-Ab-2; GM-Tg-bovg-T14731-Ab-1/ GM-Tg-bovg-T14731-Ab-2; GM-Tg-equg-T14731-Ab-1/ GM-Tg-equg-T14731-Ab-2 |
| Products Name | Anti-SIRT1 monoclonal antibody |
| Format | mab |
| Target Name | SIRT1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SIRT1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T14731 |
| Target Name | SIRT1 |
| Gene ID | 23411,93759,309757,695682,489012,101087610,613629,100072571 |
| Gene Symbol and Synonyms | SIR2,Sir2a,SIR2alpha,SIR2L1,SIRT1,sirtuin-1 |
| Uniprot Accession | Q96EB6,A0A0G2JZ79 |
| Uniprot Entry Name | SIR1_HUMAN,SIR1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000096717 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SIRT1, gene name: SIRT1, also named as SIR2, SIR2L1, SIR2alpha. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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