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Anti-FAS/ FASN/ OA-519 monoclonal antibody
Anti-FAS/ FASN/ OA-519 antibody for FACS & in-vivo assay
Go to FASN/FASN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T16514-Ab-1/ GM-Tg-hg-T16514-Ab-2 | Anti-Human FASN monoclonal antibody | Human |
| GM-Tg-rg-T16514-Ab-1/ GM-Tg-rg-T16514-Ab-2 | Anti-Rat FASN monoclonal antibody | Rat |
| GM-Tg-mg-T16514-Ab-1/ GM-Tg-mg-T16514-Ab-2 | Anti-Mouse FASN monoclonal antibody | Mouse |
| GM-Tg-cynog-T16514-Ab-1/ GM-Tg-cynog-T16514-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FASN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T16514-Ab-1/ GM-Tg-felg-T16514-Ab-2 | Anti-Feline FASN monoclonal antibody | Feline |
| GM-Tg-cang-T16514-Ab-1/ GM-Tg-cang-T16514-Ab-2 | Anti-Canine FASN monoclonal antibody | Canine |
| GM-Tg-bovg-T16514-Ab-1/ GM-Tg-bovg-T16514-Ab-2 | Anti-Bovine FASN monoclonal antibody | Bovine |
| GM-Tg-equg-T16514-Ab-1/ GM-Tg-equg-T16514-Ab-2 | Anti-Equine FASN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T16514-Ab-1/ GM-Tg-hg-T16514-Ab-2; GM-Tg-rg-T16514-Ab-1/ GM-Tg-rg-T16514-Ab-2; GM-Tg-mg-T16514-Ab-1/ GM-Tg-mg-T16514-Ab-2; GM-Tg-cynog-T16514-Ab-1/ GM-Tg-cynog-T16514-Ab-2; GM-Tg-felg-T16514-Ab-1/ GM-Tg-felg-T16514-Ab-2; GM-Tg-cang-T16514-Ab-1/ GM-Tg-cang-T16514-Ab-2; GM-Tg-bovg-T16514-Ab-1/ GM-Tg-bovg-T16514-Ab-2; GM-Tg-equg-T16514-Ab-1/ GM-Tg-equg-T16514-Ab-2 |
| Products Name | Anti-FASN monoclonal antibody |
| Format | mab |
| Target Name | FASN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FASN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FAS/ FASN/ OA-519 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T16514 |
| Target Name | FASN |
| Gene ID | 2194,14104,50671,715708,483378,100270775,281152,100057311 |
| Gene Symbol and Synonyms | A630082H08Rik,FAS,FASN,OA-519,SDR27X1 |
| Uniprot Accession | P49327,P12785,Q71SP7 |
| Uniprot Entry Name | FAS_HUMAN,FAS_RAT,FAS_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000169710 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FASN, gene name: FASN, also named as FAS, OA-519, SDR27X1. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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