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Anti-JAK3/ JAK-3/ JAK-3_HUMAN monoclonal antibody
Anti-JAK3/ JAK-3/ JAK-3_HUMAN antibody for FACS & in-vivo assay
Go to JAK-3/JAK3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23172-Ab-1/ GM-Tg-hg-T23172-Ab-2 | Anti-Human JAK-3/JAK3 monoclonal antibody | Human |
| GM-Tg-rg-T23172-Ab-1/ GM-Tg-rg-T23172-Ab-2 | Anti-Rat JAK-3/JAK3 monoclonal antibody | Rat |
| GM-Tg-mg-T23172-Ab-1/ GM-Tg-mg-T23172-Ab-2 | Anti-Mouse JAK-3/JAK3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T23172-Ab-1/ GM-Tg-cynog-T23172-Ab-2 | Anti-Cynomolgus/ Rhesus macaque JAK-3/JAK3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23172-Ab-1/ GM-Tg-felg-T23172-Ab-2 | Anti-Feline JAK-3/JAK3 monoclonal antibody | Feline |
| GM-Tg-cang-T23172-Ab-1/ GM-Tg-cang-T23172-Ab-2 | Anti-Canine JAK-3/JAK3 monoclonal antibody | Canine |
| GM-Tg-bovg-T23172-Ab-1/ GM-Tg-bovg-T23172-Ab-2 | Anti-Bovine JAK-3/JAK3 monoclonal antibody | Bovine |
| GM-Tg-equg-T23172-Ab-1/ GM-Tg-equg-T23172-Ab-2 | Anti-Equine JAK-3/JAK3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23172-Ab-1/ GM-Tg-hg-T23172-Ab-2; GM-Tg-rg-T23172-Ab-1/ GM-Tg-rg-T23172-Ab-2; GM-Tg-mg-T23172-Ab-1/ GM-Tg-mg-T23172-Ab-2; GM-Tg-cynog-T23172-Ab-1/ GM-Tg-cynog-T23172-Ab-2; GM-Tg-felg-T23172-Ab-1/ GM-Tg-felg-T23172-Ab-2; GM-Tg-cang-T23172-Ab-1/ GM-Tg-cang-T23172-Ab-2; GM-Tg-bovg-T23172-Ab-1/ GM-Tg-bovg-T23172-Ab-2; GM-Tg-equg-T23172-Ab-1/ GM-Tg-equg-T23172-Ab-2 |
| Products Name | Anti-JAK-3/JAK3 monoclonal antibody |
| Format | mab |
| Target Name | JAK-3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-JAK-3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species JAK3/ JAK-3/ JAK-3_HUMAN VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T23172 |
| Target Name | JAK-3 |
| Gene ID | 3718,16453,25326,720040,610004,101092339,538276,100147451 |
| Gene Symbol and Synonyms | fae,JAK-3,JAK3,JAK3_HUMAN,JAKL,L-JAK,LJAK,RATJAK3,wil |
| Uniprot Accession | P52333,Q63272 |
| Uniprot Entry Name | JAK3_HUMAN,JAK3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000105639 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: JAK-3, gene name: JAK3, also named as JAK-3_HUMAN, JAKL, L-JAK, LJAK, JAK3. The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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