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Anti-PROC/ APC/ PC1 functional antibody
Anti-PROC/ APC/ PC1 functional antibody for cell culture, ELISA & in-vivo assay
Go to PROC/PROC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T24836-Ab-1/ GM-Tg-hg-T24836-Ab-2 | Anti-Human PROC monoclonal antibody | Human |
| GM-Tg-rg-T24836-Ab-1/ GM-Tg-rg-T24836-Ab-2 | Anti-Rat PROC monoclonal antibody | Rat |
| GM-Tg-mg-T24836-Ab-1/ GM-Tg-mg-T24836-Ab-2 | Anti-Mouse PROC monoclonal antibody | Mouse |
| GM-Tg-cynog-T24836-Ab-1/ GM-Tg-cynog-T24836-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PROC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T24836-Ab-1/ GM-Tg-felg-T24836-Ab-2 | Anti-Feline PROC monoclonal antibody | Feline |
| GM-Tg-cang-T24836-Ab-1/ GM-Tg-cang-T24836-Ab-2 | Anti-Canine PROC monoclonal antibody | Canine |
| GM-Tg-bovg-T24836-Ab-1/ GM-Tg-bovg-T24836-Ab-2 | Anti-Bovine PROC monoclonal antibody | Bovine |
| GM-Tg-equg-T24836-Ab-1/ GM-Tg-equg-T24836-Ab-2 | Anti-Equine PROC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T24836-Ab-1/ GM-Tg-hg-T24836-Ab-2; GM-Tg-rg-T24836-Ab-1/ GM-Tg-rg-T24836-Ab-2; GM-Tg-mg-T24836-Ab-1/ GM-Tg-mg-T24836-Ab-2; GM-Tg-cynog-T24836-Ab-1/ GM-Tg-cynog-T24836-Ab-2; GM-Tg-felg-T24836-Ab-1/ GM-Tg-felg-T24836-Ab-2; GM-Tg-cang-T24836-Ab-1/ GM-Tg-cang-T24836-Ab-2; GM-Tg-bovg-T24836-Ab-1/ GM-Tg-bovg-T24836-Ab-2; GM-Tg-equg-T24836-Ab-1/ GM-Tg-equg-T24836-Ab-2 |
| Products Name | Anti-PROC monoclonal antibody |
| Format | mab |
| Target Name | PROC |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PROC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T24836-Ag-1 | Recombinant multi-species PROC/ APC/ PC1 protein |
| ORF Viral Vector | pGMLV000878 | human PROC Lentivirus plasmid |
| ORF Viral Vector | vGMLV000878 | human PROC Lentivirus particle |
| ORF Viral Vector | vGMLP003901 | human PROC Lentivirus particle |
| ORF Viral Vector | vGMLV000573 | human PROC-mu Lentivirus particle |
| ORF Viral Vector | pGMLV000573 | human PROC-mu Lentivirus plasmid |
| ORF Viral Vector | pGMLP002690 | human PROC Lentivirus plasmid |
| ORF Viral Vector | vGMLP003902 | human PROC Lentivirus particle |
| ORF Viral Vector | pGMLP003902 | human PROC Lentivirus plasmid |
| ORF Viral Vector | pGMLP003901 | human PROC Lentivirus plasmid |
| ORF Viral Vector | vGMLP002690 | human PROC Lentivirus particle |
| ORF Viral Vector | pGMLPm004981 | mouse Proc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004981 | mouse Proc Lentivirus particle |
Target information
| Target ID | GM-T24836 |
| Target Name | PROC |
| Gene ID | 5624,19123,25268,699077,476104,101096161,281428,100051306 |
| Gene Symbol and Synonyms | APC,PC,PROC,PROC1,THPH3,THPH4 |
| Uniprot Accession | P04070,P31394,Q28506,Q28278,Q28412,P00745,Q28380 |
| Uniprot Entry Name | PROC_HUMAN,PROC_MACMU,PROC_RAT,PROC_FELCA,PROC_CANLF,PROC_BOVIN,PROC_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000115718 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PROC, gene name: PROC, also named as APC, PC1, THPH3, THPH4, PROC. This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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