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Anti-EDN1/ ARCND3/ ET1 functional antibody
Anti-EDN1/ ARCND3/ ET1 functional antibody for cell culture, ELISA & in-vivo assay
Go to EDN1/EDN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T25076-Ab-1/ GM-Tg-hg-T25076-Ab-2 | Anti-Human EDN1 monoclonal antibody | Human |
| GM-Tg-rg-T25076-Ab-1/ GM-Tg-rg-T25076-Ab-2 | Anti-Rat EDN1 monoclonal antibody | Rat |
| GM-Tg-mg-T25076-Ab-1/ GM-Tg-mg-T25076-Ab-2 | Anti-Mouse EDN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T25076-Ab-1/ GM-Tg-cynog-T25076-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EDN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T25076-Ab-1/ GM-Tg-felg-T25076-Ab-2 | Anti-Feline EDN1 monoclonal antibody | Feline |
| GM-Tg-cang-T25076-Ab-1/ GM-Tg-cang-T25076-Ab-2 | Anti-Canine EDN1 monoclonal antibody | Canine |
| GM-Tg-bovg-T25076-Ab-1/ GM-Tg-bovg-T25076-Ab-2 | Anti-Bovine EDN1 monoclonal antibody | Bovine |
| GM-Tg-equg-T25076-Ab-1/ GM-Tg-equg-T25076-Ab-2 | Anti-Equine EDN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T25076-Ab-1/ GM-Tg-hg-T25076-Ab-2; GM-Tg-rg-T25076-Ab-1/ GM-Tg-rg-T25076-Ab-2; GM-Tg-mg-T25076-Ab-1/ GM-Tg-mg-T25076-Ab-2; GM-Tg-cynog-T25076-Ab-1/ GM-Tg-cynog-T25076-Ab-2; GM-Tg-felg-T25076-Ab-1/ GM-Tg-felg-T25076-Ab-2; GM-Tg-cang-T25076-Ab-1/ GM-Tg-cang-T25076-Ab-2; GM-Tg-bovg-T25076-Ab-1/ GM-Tg-bovg-T25076-Ab-2; GM-Tg-equg-T25076-Ab-1/ GM-Tg-equg-T25076-Ab-2 |
| Products Name | Anti-EDN1 monoclonal antibody |
| Format | mab |
| Target Name | EDN1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EDN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T25076-Ag-1 | Recombinant multi-species EDN1/ ARCND3/ ET1 protein |
| ORF Viral Vector | vGMLP001214 | human EDN1 Lentivirus particle |
| ORF Viral Vector | pGMLP001214 | human EDN1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000129 | rat Edn1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001045 | mouse Edn1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000129 | rat Edn1 Lentivirus particle |
| ORF Viral Vector | vGMLPm001045 | mouse Edn1 Lentivirus particle |
Target information
| Target ID | GM-T25076 |
| Target Name | EDN1 |
| Gene ID | 1906,13614,24323,699982,403424,494214,281137,100034060 |
| Gene Symbol and Synonyms | ARCND3,EDN1,ET-1,ET1,HDLCQ7,PPET1,preproET,QME |
| Uniprot Accession | P05305,P22388,P13206,Q5NRQ1,P17322 |
| Uniprot Entry Name | EDN1_HUMAN,EDN1_RAT,EDN1_FELCA,EDN1_CANLF,EDN1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000078401 |
| Target Classification | N/A |
The target: EDN1, gene name: EDN1, also named as ARCND3, ET1, HDLCQ7, PPET1, QME. This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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