- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-c-Fos monoclonal antibody
Pre-made anti-c-Fos monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to c-Fos/FOS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28025-Ab-1/ GM-Tg-hg-T28025-Ab-2 | Anti-Human c-Fos/FOS monoclonal antibody | Human |
| GM-Tg-rg-T28025-Ab-1/ GM-Tg-rg-T28025-Ab-2 | Anti-Rat c-Fos/FOS monoclonal antibody | Rat |
| GM-Tg-mg-T28025-Ab-1/ GM-Tg-mg-T28025-Ab-2 | Anti-Mouse c-Fos/FOS monoclonal antibody | Mouse |
| GM-Tg-cynog-T28025-Ab-1/ GM-Tg-cynog-T28025-Ab-2 | Anti-Cynomolgus/ Rhesus macaque c-Fos/FOS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28025-Ab-1/ GM-Tg-felg-T28025-Ab-2 | Anti-Feline c-Fos/FOS monoclonal antibody | Feline |
| GM-Tg-cang-T28025-Ab-1/ GM-Tg-cang-T28025-Ab-2 | Anti-Canine c-Fos/FOS monoclonal antibody | Canine |
| GM-Tg-bovg-T28025-Ab-1/ GM-Tg-bovg-T28025-Ab-2 | Anti-Bovine c-Fos/FOS monoclonal antibody | Bovine |
| GM-Tg-equg-T28025-Ab-1/ GM-Tg-equg-T28025-Ab-2 | Anti-Equine c-Fos/FOS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T28025-Ab-1/ GM-Tg-hg-T28025-Ab-2; GM-Tg-rg-T28025-Ab-1/ GM-Tg-rg-T28025-Ab-2; GM-Tg-mg-T28025-Ab-1/ GM-Tg-mg-T28025-Ab-2; GM-Tg-cynog-T28025-Ab-1/ GM-Tg-cynog-T28025-Ab-2; GM-Tg-felg-T28025-Ab-1/ GM-Tg-felg-T28025-Ab-2; GM-Tg-cang-T28025-Ab-1/ GM-Tg-cang-T28025-Ab-2; GM-Tg-bovg-T28025-Ab-1/ GM-Tg-bovg-T28025-Ab-2; GM-Tg-equg-T28025-Ab-1/ GM-Tg-equg-T28025-Ab-2 |
| Products Name | Anti-c-Fos/FOS monoclonal antibody |
| Format | mab |
| Target Name | c-Fos |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-c-Fos monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T28025-Ag-1 | Recombinant multi-species FOS/ c-Fos/ AP-1 protein |
| ORF Viral Vector | pGMLP001940 | human FOS Lentivirus plasmid |
| ORF Viral Vector | vGMAP000475 | Human FOS Adenovirus particle |
| ORF Viral Vector | vGMAD000494 | human FOS Adenovirus particle |
| ORF Viral Vector | vGMLP001940 | human FOS Lentivirus particle |
| ORF Viral Vector | pGMAP000475 | Human FOS Adenovirus plasmid |
| ORF Viral Vector | pGMAD000494 | human FOS Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002314 | mouse Fos Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002314 | mouse Fos Lentivirus particle |
Target information
| Target ID | GM-T28025 |
| Target Name | c-Fos |
| Gene ID | 2353,14281,314322,702077,490792,493935,280795,100051632 |
| Gene Symbol and Synonyms | AP-1,C-FOS,cFos,D12Rfj1,FOS,p55 |
| Uniprot Accession | P01100,P12841,Q8HZP6,O77628 |
| Uniprot Entry Name | FOS_HUMAN,FOS_RAT,FOS_FELCA,FOS_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000170345 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: c-Fos, gene name: FOS, also named as AP-1, C-FOS, p55. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
