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Anti-GDF15/ GDF-15/ MIC-1 functional antibody
Anti-GDF15/ GDF-15/ MIC-1 functional antibody for cell culture, ELISA & in-vivo assay
Go to GDF15/GDF15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T33245-Ab-1/ GM-Tg-hg-T33245-Ab-2 | Anti-Human GDF15 monoclonal antibody | Human |
| GM-Tg-rg-T33245-Ab-1/ GM-Tg-rg-T33245-Ab-2 | Anti-Rat GDF15 monoclonal antibody | Rat |
| GM-Tg-mg-T33245-Ab-1/ GM-Tg-mg-T33245-Ab-2 | Anti-Mouse GDF15 monoclonal antibody | Mouse |
| GM-Tg-cynog-T33245-Ab-1/ GM-Tg-cynog-T33245-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GDF15 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T33245-Ab-1/ GM-Tg-felg-T33245-Ab-2 | Anti-Feline GDF15 monoclonal antibody | Feline |
| GM-Tg-cang-T33245-Ab-1/ GM-Tg-cang-T33245-Ab-2 | Anti-Canine GDF15 monoclonal antibody | Canine |
| GM-Tg-bovg-T33245-Ab-1/ GM-Tg-bovg-T33245-Ab-2 | Anti-Bovine GDF15 monoclonal antibody | Bovine |
| GM-Tg-equg-T33245-Ab-1/ GM-Tg-equg-T33245-Ab-2 | Anti-Equine GDF15 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T33245-Ab-1/ GM-Tg-hg-T33245-Ab-2; GM-Tg-rg-T33245-Ab-1/ GM-Tg-rg-T33245-Ab-2; GM-Tg-mg-T33245-Ab-1/ GM-Tg-mg-T33245-Ab-2; GM-Tg-cynog-T33245-Ab-1/ GM-Tg-cynog-T33245-Ab-2; GM-Tg-felg-T33245-Ab-1/ GM-Tg-felg-T33245-Ab-2; GM-Tg-cang-T33245-Ab-1/ GM-Tg-cang-T33245-Ab-2; GM-Tg-bovg-T33245-Ab-1/ GM-Tg-bovg-T33245-Ab-2; GM-Tg-equg-T33245-Ab-1/ GM-Tg-equg-T33245-Ab-2 |
| Products Name | Anti-GDF15 monoclonal antibody |
| Format | mab |
| Target Name | GDF15 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GDF15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-451 | Pre-Made Ponsegromab biosimilar, Whole mAb, Anti-GDF15 Antibody: Anti-GDF-15/MIC-1/MIC1/NAG-1/PDF/PLAB/PTGFB therapeutic antibody |
| Target Antigen | GM-Tg-g-T33245-Ag-1 | Recombinant multi-species GDF15/ GDF-15/ MIC-1 protein |
| Cytokine | GM-Tg-g-T33245-Ag-1 | growth differentiation factor 15 (GDF15) protein |
| ORF Viral Vector | vGMLP000446 | human GDF15 Lentivirus particle |
| ORF Viral Vector | pGMLP000446 | human GDF15 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004533 | mouse Gdf15 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004533 | mouse Gdf15 Lentivirus particle |
Target information
| Target ID | GM-T33245 |
| Target Name | GDF15 |
| Gene ID | 9518,23886,29455,719466,484822,101086633,618677,111769675 |
| Gene Symbol and Synonyms | GDF-15,GDF15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB,SBF |
| Uniprot Accession | Q99988,Q9Z0J6 |
| Uniprot Entry Name | GDF15_HUMAN,GDF15_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Diagnostics Biomarker, INN Index, Cytokine Target |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000130513 |
| Target Classification | N/A |
The target: GDF15, gene name: GDF15, also named as GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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