Anti-STS/ ARSC/ ARSC1 monoclonal antibody

Anti-STS/ ARSC/ ARSC1 antibody for FACS & in-vivo assay

Target products collectionGo to STS/STS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T33489-Ab-1/ GM-Tg-hg-T33489-Ab-2Anti-Human STS monoclonal antibodyHuman
GM-Tg-rg-T33489-Ab-1/ GM-Tg-rg-T33489-Ab-2Anti-Rat STS monoclonal antibodyRat
GM-Tg-mg-T33489-Ab-1/ GM-Tg-mg-T33489-Ab-2Anti-Mouse STS monoclonal antibodyMouse
GM-Tg-cynog-T33489-Ab-1/ GM-Tg-cynog-T33489-Ab-2Anti-Cynomolgus/ Rhesus macaque STS monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T33489-Ab-1/ GM-Tg-felg-T33489-Ab-2Anti-Feline STS monoclonal antibodyFeline
GM-Tg-cang-T33489-Ab-1/ GM-Tg-cang-T33489-Ab-2Anti-Canine STS monoclonal antibodyCanine
GM-Tg-bovg-T33489-Ab-1/ GM-Tg-bovg-T33489-Ab-2Anti-Bovine STS monoclonal antibodyBovine
GM-Tg-equg-T33489-Ab-1/ GM-Tg-equg-T33489-Ab-2Anti-Equine STS monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T33489-Ab-1/ GM-Tg-hg-T33489-Ab-2; GM-Tg-rg-T33489-Ab-1/ GM-Tg-rg-T33489-Ab-2;
GM-Tg-mg-T33489-Ab-1/ GM-Tg-mg-T33489-Ab-2; GM-Tg-cynog-T33489-Ab-1/ GM-Tg-cynog-T33489-Ab-2;
GM-Tg-felg-T33489-Ab-1/ GM-Tg-felg-T33489-Ab-2; GM-Tg-cang-T33489-Ab-1/ GM-Tg-cang-T33489-Ab-2;
GM-Tg-bovg-T33489-Ab-1/ GM-Tg-bovg-T33489-Ab-2; GM-Tg-equg-T33489-Ab-1/ GM-Tg-equg-T33489-Ab-2
Products NameAnti-STS monoclonal antibody
Formatmab
Target NameSTS
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-STS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species STS/ ARSC/ ARSC1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T33489
    Target NameSTS
    Gene ID412,20905,707799,491727,101082979,509206,100034102
    Gene Symbol and SynonymsARSC,ARSC1,ASC,ES,SSDD,STS,XLI
    Uniprot AccessionP08842
    Uniprot Entry NameSTS_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000101846
    Target ClassificationN/A

    The target: STS, gene name: STS, also named as ARSC, ARSC1, ASC, ES, SSDD, XLI. This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.