Anti-p105 monoclonal antibody
Pre-made anti-p105 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T40192-Ab-1/ GM-Tg-hg-T40192-Ab-2 | Anti-Human p105/NFKB1 monoclonal antibody | Human |
GM-Tg-rg-T40192-Ab-1/ GM-Tg-rg-T40192-Ab-2 | Anti-Rat p105/NFKB1 monoclonal antibody | Rat |
GM-Tg-mg-T40192-Ab-1/ GM-Tg-mg-T40192-Ab-2 | Anti-Mouse p105/NFKB1 monoclonal antibody | Mouse |
GM-Tg-cynog-T40192-Ab-1/ GM-Tg-cynog-T40192-Ab-2 | Anti-Cynomolgus/ Rhesus macaque p105/NFKB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T40192-Ab-1/ GM-Tg-felg-T40192-Ab-2 | Anti-Feline p105/NFKB1 monoclonal antibody | Feline |
GM-Tg-cang-T40192-Ab-1/ GM-Tg-cang-T40192-Ab-2 | Anti-Canine p105/NFKB1 monoclonal antibody | Canine |
GM-Tg-bovg-T40192-Ab-1/ GM-Tg-bovg-T40192-Ab-2 | Anti-Bovine p105/NFKB1 monoclonal antibody | Bovine |
GM-Tg-equg-T40192-Ab-1/ GM-Tg-equg-T40192-Ab-2 | Anti-Equine p105/NFKB1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T40192-Ab-1/ GM-Tg-hg-T40192-Ab-2; GM-Tg-rg-T40192-Ab-1/ GM-Tg-rg-T40192-Ab-2; GM-Tg-mg-T40192-Ab-1/ GM-Tg-mg-T40192-Ab-2; GM-Tg-cynog-T40192-Ab-1/ GM-Tg-cynog-T40192-Ab-2; GM-Tg-felg-T40192-Ab-1/ GM-Tg-felg-T40192-Ab-2; GM-Tg-cang-T40192-Ab-1/ GM-Tg-cang-T40192-Ab-2; GM-Tg-bovg-T40192-Ab-1/ GM-Tg-bovg-T40192-Ab-2; GM-Tg-equg-T40192-Ab-1/ GM-Tg-equg-T40192-Ab-2 |
Products Name | Anti-p105/NFKB1 monoclonal antibody |
Format | mab |
Target Name | p105 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-p105 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T40192-Ag-1 | Recombinant multi-species NFKB1/ p105/ CVID12 protein |
ORF Viral Vector | pGMLPm004475 | mouse Nfkb1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm004475 | mouse Nfkb1 Lentivirus particle |
Target information
Target ID | GM-T40192 |
Target Name | p105 |
Gene ID | 4790,18033,81736,710324,442859,100142683,616115,100067894 |
Gene Symbol and Synonyms | CVID12,EBP-1,KBF1,NF-kappa-B1,NF-kappaB,NF-kappaB1,NF-kappabeta,NF-kB,NF-kB1,NFkappaB,NFKB-p105,NFKB-p50,NFKB1,p105,p50,p50/p105 |
Uniprot Accession | P19838,Q63369,Q6F3J0 |
Uniprot Entry Name | NFKB1_HUMAN,NFKB1_RAT,NFKB1_CANLF |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000109320 |
Target Classification | Tumor-associated antigen (TAA) |
The target: p105, gene name: NFKB1, also named as CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B1, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50. This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.