Anti-PTPRC/ B220/ CD45 monoclonal antibody

Anti-PTPRC/ B220/ CD45 antibody for FACS & in-vivo assay

Target products collectionGo to PTPRC/PTPRC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T43115-Ab-1/ GM-Tg-hg-T43115-Ab-2Anti-Human PTPRC monoclonal antibodyHuman
GM-Tg-rg-T43115-Ab-1/ GM-Tg-rg-T43115-Ab-2Anti-Rat PTPRC monoclonal antibodyRat
GM-Tg-mg-T43115-Ab-1/ GM-Tg-mg-T43115-Ab-2Anti-Mouse PTPRC monoclonal antibodyMouse
GM-Tg-cynog-T43115-Ab-1/ GM-Tg-cynog-T43115-Ab-2Anti-Cynomolgus/ Rhesus macaque PTPRC monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T43115-Ab-1/ GM-Tg-felg-T43115-Ab-2Anti-Feline PTPRC monoclonal antibodyFeline
GM-Tg-cang-T43115-Ab-1/ GM-Tg-cang-T43115-Ab-2Anti-Canine PTPRC monoclonal antibodyCanine
GM-Tg-bovg-T43115-Ab-1/ GM-Tg-bovg-T43115-Ab-2Anti-Bovine PTPRC monoclonal antibodyBovine
GM-Tg-equg-T43115-Ab-1/ GM-Tg-equg-T43115-Ab-2Anti-Equine PTPRC monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T43115-Ab-1/ GM-Tg-hg-T43115-Ab-2; GM-Tg-rg-T43115-Ab-1/ GM-Tg-rg-T43115-Ab-2;
GM-Tg-mg-T43115-Ab-1/ GM-Tg-mg-T43115-Ab-2; GM-Tg-cynog-T43115-Ab-1/ GM-Tg-cynog-T43115-Ab-2;
GM-Tg-felg-T43115-Ab-1/ GM-Tg-felg-T43115-Ab-2; GM-Tg-cang-T43115-Ab-1/ GM-Tg-cang-T43115-Ab-2;
GM-Tg-bovg-T43115-Ab-1/ GM-Tg-bovg-T43115-Ab-2; GM-Tg-equg-T43115-Ab-1/ GM-Tg-equg-T43115-Ab-2
Products NameAnti-PTPRC monoclonal antibody
Formatmab
Target NamePTPRC
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PTPRC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-029Pre-Made Apamistamab biosimilar, Whole mAb Radiolabelled, Anti-PTPRC Antibody: Anti-B220/CD45/CD45R/GP180/L-CA/LCA/LY5/T200 therapeutic antibody
    BiosimilarGMP-Bios-INN-875Pre-Made Iodine (131I) Apamistamab Biosimilar, Radiolabelled Antibody, Anti-Ptprc Antibody: Anti-B220/CD45/CD45R/GP180/L-CA/LCA/LY5/T200 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species PTPRC/ B220/ CD45 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T43115
    Target NamePTPRC
    Gene ID5788,19264,24699,712657,101097123,407152,100061950
    Gene Symbol and SynonymsB220,CD45,CD45R,GP180,IMD105,L-CA,LCA,loc,Ly-5,LY5,Lyt-4,PTPRC,RT7,T200
    Uniprot AccessionP08575,P04157
    Uniprot Entry NamePTPRC_HUMAN,PTPRC_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000081237
    Target ClassificationTumor-associated antigen (TAA)

    The target: PTPRC, gene name: PTPRC, also named as B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.