Anti-17-beta-HSD1 monoclonal antibody

Pre-made anti-17-beta-HSD1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to 17-beta-HSD1/HSD17B1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T44011-Ab-1/ GM-Tg-hg-T44011-Ab-2Anti-Human 17-beta-HSD1/HSD17B1 monoclonal antibodyHuman
GM-Tg-rg-T44011-Ab-1/ GM-Tg-rg-T44011-Ab-2Anti-Rat 17-beta-HSD1/HSD17B1 monoclonal antibodyRat
GM-Tg-mg-T44011-Ab-1/ GM-Tg-mg-T44011-Ab-2Anti-Mouse 17-beta-HSD1/HSD17B1 monoclonal antibodyMouse
GM-Tg-cynog-T44011-Ab-1/ GM-Tg-cynog-T44011-Ab-2Anti-Cynomolgus/ Rhesus macaque 17-beta-HSD1/HSD17B1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T44011-Ab-1/ GM-Tg-felg-T44011-Ab-2Anti-Feline 17-beta-HSD1/HSD17B1 monoclonal antibodyFeline
GM-Tg-cang-T44011-Ab-1/ GM-Tg-cang-T44011-Ab-2Anti-Canine 17-beta-HSD1/HSD17B1 monoclonal antibodyCanine
GM-Tg-bovg-T44011-Ab-1/ GM-Tg-bovg-T44011-Ab-2Anti-Bovine 17-beta-HSD1/HSD17B1 monoclonal antibodyBovine
GM-Tg-equg-T44011-Ab-1/ GM-Tg-equg-T44011-Ab-2Anti-Equine 17-beta-HSD1/HSD17B1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T44011-Ab-1/ GM-Tg-hg-T44011-Ab-2; GM-Tg-rg-T44011-Ab-1/ GM-Tg-rg-T44011-Ab-2;
GM-Tg-mg-T44011-Ab-1/ GM-Tg-mg-T44011-Ab-2; GM-Tg-cynog-T44011-Ab-1/ GM-Tg-cynog-T44011-Ab-2;
GM-Tg-felg-T44011-Ab-1/ GM-Tg-felg-T44011-Ab-2; GM-Tg-cang-T44011-Ab-1/ GM-Tg-cang-T44011-Ab-2;
GM-Tg-bovg-T44011-Ab-1/ GM-Tg-bovg-T44011-Ab-2; GM-Tg-equg-T44011-Ab-1/ GM-Tg-equg-T44011-Ab-2
Products NameAnti-17-beta-HSD1/HSD17B1 monoclonal antibody
Formatmab
Target Name17-beta-HSD1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-17-beta-HSD1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T44011-Ag-1Recombinant multi-species DHB1/ 17-beta-HSD1/ HSD17B1 protein
    ORF Viral VectorpGMLP000906human HSD17B1 Lentivirus plasmid
    ORF Viral VectorvGMLP000906human HSD17B1 Lentivirus particle
    ORF Viral VectorpGMLPm005149mouse Hsd17b1 Lentivirus plasmid
    ORF Viral VectorvGMLPm005149mouse Hsd17b1 Lentivirus particle


    Target information

    Target IDGM-T44011
    Target Name17-beta-HSD1
    Gene ID3292,15485,25322,710392,607570,101091417,353107,100036556
    Gene Symbol and Synonyms17-beta-HSD,17beta-HSD,17BHD1,17HSDB1,20-alpha-HSD,E2DH,EDH17B2,EDHB17,HSD17,HSD17B1,Hsd17ba,SDR28C1
    Uniprot AccessionP14061,P51657
    Uniprot Entry NameDHB1_HUMAN,DHB1_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000108786
    Target ClassificationTumor-associated antigen (TAA)

    The target: 17-beta-HSD1, gene name: HSD17B1, also named as 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1. This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.