Anti-17-beta-HSD1 monoclonal antibody
Pre-made anti-17-beta-HSD1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T44011-Ab-1/ GM-Tg-hg-T44011-Ab-2 | Anti-Human 17-beta-HSD1/HSD17B1 monoclonal antibody | Human |
GM-Tg-rg-T44011-Ab-1/ GM-Tg-rg-T44011-Ab-2 | Anti-Rat 17-beta-HSD1/HSD17B1 monoclonal antibody | Rat |
GM-Tg-mg-T44011-Ab-1/ GM-Tg-mg-T44011-Ab-2 | Anti-Mouse 17-beta-HSD1/HSD17B1 monoclonal antibody | Mouse |
GM-Tg-cynog-T44011-Ab-1/ GM-Tg-cynog-T44011-Ab-2 | Anti-Cynomolgus/ Rhesus macaque 17-beta-HSD1/HSD17B1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T44011-Ab-1/ GM-Tg-felg-T44011-Ab-2 | Anti-Feline 17-beta-HSD1/HSD17B1 monoclonal antibody | Feline |
GM-Tg-cang-T44011-Ab-1/ GM-Tg-cang-T44011-Ab-2 | Anti-Canine 17-beta-HSD1/HSD17B1 monoclonal antibody | Canine |
GM-Tg-bovg-T44011-Ab-1/ GM-Tg-bovg-T44011-Ab-2 | Anti-Bovine 17-beta-HSD1/HSD17B1 monoclonal antibody | Bovine |
GM-Tg-equg-T44011-Ab-1/ GM-Tg-equg-T44011-Ab-2 | Anti-Equine 17-beta-HSD1/HSD17B1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T44011-Ab-1/ GM-Tg-hg-T44011-Ab-2; GM-Tg-rg-T44011-Ab-1/ GM-Tg-rg-T44011-Ab-2; GM-Tg-mg-T44011-Ab-1/ GM-Tg-mg-T44011-Ab-2; GM-Tg-cynog-T44011-Ab-1/ GM-Tg-cynog-T44011-Ab-2; GM-Tg-felg-T44011-Ab-1/ GM-Tg-felg-T44011-Ab-2; GM-Tg-cang-T44011-Ab-1/ GM-Tg-cang-T44011-Ab-2; GM-Tg-bovg-T44011-Ab-1/ GM-Tg-bovg-T44011-Ab-2; GM-Tg-equg-T44011-Ab-1/ GM-Tg-equg-T44011-Ab-2 |
Products Name | Anti-17-beta-HSD1/HSD17B1 monoclonal antibody |
Format | mab |
Target Name | 17-beta-HSD1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-17-beta-HSD1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T44011-Ag-1 | Recombinant multi-species DHB1/ 17-beta-HSD1/ HSD17B1 protein |
ORF Viral Vector | pGMLP000906 | human HSD17B1 Lentivirus plasmid |
ORF Viral Vector | vGMLP000906 | human HSD17B1 Lentivirus particle |
ORF Viral Vector | pGMLPm005149 | mouse Hsd17b1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm005149 | mouse Hsd17b1 Lentivirus particle |
Target information
Target ID | GM-T44011 |
Target Name | 17-beta-HSD1 |
Gene ID | 3292,15485,25322,710392,607570,101091417,353107,100036556 |
Gene Symbol and Synonyms | 17-beta-HSD,17beta-HSD,17BHD1,17HSDB1,20-alpha-HSD,E2DH,EDH17B2,EDHB17,HSD17,HSD17B1,Hsd17ba,SDR28C1 |
Uniprot Accession | P14061,P51657 |
Uniprot Entry Name | DHB1_HUMAN,DHB1_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000108786 |
Target Classification | Tumor-associated antigen (TAA) |
The target: 17-beta-HSD1, gene name: HSD17B1, also named as 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1. This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.