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Anti-CDK9 monoclonal antibody
Pre-made anti-CDK9 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CDK9/CDK9 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T44458-Ab-1/ GM-Tg-hg-T44458-Ab-2 | Anti-Human CDK9 monoclonal antibody | Human |
| GM-Tg-rg-T44458-Ab-1/ GM-Tg-rg-T44458-Ab-2 | Anti-Rat CDK9 monoclonal antibody | Rat |
| GM-Tg-mg-T44458-Ab-1/ GM-Tg-mg-T44458-Ab-2 | Anti-Mouse CDK9 monoclonal antibody | Mouse |
| GM-Tg-cynog-T44458-Ab-1/ GM-Tg-cynog-T44458-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CDK9 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T44458-Ab-1/ GM-Tg-felg-T44458-Ab-2 | Anti-Feline CDK9 monoclonal antibody | Feline |
| GM-Tg-cang-T44458-Ab-1/ GM-Tg-cang-T44458-Ab-2 | Anti-Canine CDK9 monoclonal antibody | Canine |
| GM-Tg-bovg-T44458-Ab-1/ GM-Tg-bovg-T44458-Ab-2 | Anti-Bovine CDK9 monoclonal antibody | Bovine |
| GM-Tg-equg-T44458-Ab-1/ GM-Tg-equg-T44458-Ab-2 | Anti-Equine CDK9 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T44458-Ab-1/ GM-Tg-hg-T44458-Ab-2; GM-Tg-rg-T44458-Ab-1/ GM-Tg-rg-T44458-Ab-2; GM-Tg-mg-T44458-Ab-1/ GM-Tg-mg-T44458-Ab-2; GM-Tg-cynog-T44458-Ab-1/ GM-Tg-cynog-T44458-Ab-2; GM-Tg-felg-T44458-Ab-1/ GM-Tg-felg-T44458-Ab-2; GM-Tg-cang-T44458-Ab-1/ GM-Tg-cang-T44458-Ab-2; GM-Tg-bovg-T44458-Ab-1/ GM-Tg-bovg-T44458-Ab-2; GM-Tg-equg-T44458-Ab-1/ GM-Tg-equg-T44458-Ab-2 |
| Products Name | Anti-CDK9 monoclonal antibody |
| Format | mab |
| Target Name | CDK9 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CDK9 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T44458-Ag-1 | Recombinant multi-species CDK9/ C-2k/ CDC2L4 protein |
| ORF Viral Vector | pGMLPm002521 | mouse Cdk9 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002521 | mouse Cdk9 Lentivirus particle |
Target information
| Target ID | GM-T44458 |
| Target Name | CDK9 |
| Gene ID | 1025,107951,362110,699840,100855805,101097767,520580,100070437 |
| Gene Symbol and Synonyms | C-2k,CDC2L4,CDK9,CTK1,PITALRE,TAK |
| Uniprot Accession | P50750,Q641Z4,Q5EAB2 |
| Uniprot Entry Name | CDK9_HUMAN,CDK9_RAT,CDK9_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000136807 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: CDK9, gene name: CDK9, also named as C-2k, CDC2L4, CTK1, PITALRE, TAK. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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