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Anti-PPIA/ CYPA/ CYPH functional antibody
Anti-PPIA/ CYPA/ CYPH functional antibody for cell culture, ELISA & in-vivo assay
Go to PPIA/PPIA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T47081-Ab-1/ GM-Tg-hg-T47081-Ab-2 | Anti-Human PPIA monoclonal antibody | Human |
| GM-Tg-rg-T47081-Ab-1/ GM-Tg-rg-T47081-Ab-2 | Anti-Rat PPIA monoclonal antibody | Rat |
| GM-Tg-mg-T47081-Ab-1/ GM-Tg-mg-T47081-Ab-2 | Anti-Mouse PPIA monoclonal antibody | Mouse |
| GM-Tg-cynog-T47081-Ab-1/ GM-Tg-cynog-T47081-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPIA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T47081-Ab-1/ GM-Tg-felg-T47081-Ab-2 | Anti-Feline PPIA monoclonal antibody | Feline |
| GM-Tg-cang-T47081-Ab-1/ GM-Tg-cang-T47081-Ab-2 | Anti-Canine PPIA monoclonal antibody | Canine |
| GM-Tg-bovg-T47081-Ab-1/ GM-Tg-bovg-T47081-Ab-2 | Anti-Bovine PPIA monoclonal antibody | Bovine |
| GM-Tg-equg-T47081-Ab-1/ GM-Tg-equg-T47081-Ab-2 | Anti-Equine PPIA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T47081-Ab-1/ GM-Tg-hg-T47081-Ab-2; GM-Tg-rg-T47081-Ab-1/ GM-Tg-rg-T47081-Ab-2; GM-Tg-mg-T47081-Ab-1/ GM-Tg-mg-T47081-Ab-2; GM-Tg-cynog-T47081-Ab-1/ GM-Tg-cynog-T47081-Ab-2; GM-Tg-felg-T47081-Ab-1/ GM-Tg-felg-T47081-Ab-2; GM-Tg-cang-T47081-Ab-1/ GM-Tg-cang-T47081-Ab-2; GM-Tg-bovg-T47081-Ab-1/ GM-Tg-bovg-T47081-Ab-2; GM-Tg-equg-T47081-Ab-1/ GM-Tg-equg-T47081-Ab-2 |
| Products Name | Anti-PPIA monoclonal antibody |
| Format | mab |
| Target Name | PPIA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PPIA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T47081-Ag-1 | Recombinant multi-species PPIA/ CYPA/ CYPH protein |
| ORF Viral Vector | pGMAP000039 | Human PPIA Adenovirus plasmid |
| ORF Viral Vector | vGMAP000039 | Human PPIA Adenovirus particle |
| ORF Viral Vector | pGMAD000285 | rat Ppia Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000015 | mouse Ppia Lentivirus plasmid |
| ORF Viral Vector | vGMAD000285 | rat Ppia Adenovirus particle |
| ORF Viral Vector | vGMLPm000015 | mouse Ppia Lentivirus particle |
Target information
| Target ID | GM-T47081 |
| Target Name | PPIA |
| Gene ID | 5478,268373,25518,574102,608151,493966,281418,100052020 |
| Gene Symbol and Synonyms | Cphn,CYCA,CyP-18,CyP-A,CYPA,CYPH,HEL-S-69p,MT-ND1,MTND1,NADH1,ND1,p1B15,p31,PPIA,SP18 |
| Uniprot Accession | P62937,P10111,P62940,P48900,Q8HXS3,P62935 |
| Uniprot Entry Name | PPIA_HUMAN,PPIA_MACMU,PPIA_RAT,NU1M_FELCA,PPIA_FELCA,PPIA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000196262 |
| Target Classification | N/A |
The target: PPIA, gene name: PPIA, also named as CYPA, CYPH, HEL-S-69p. This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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