Anti-CD86/ FUN1/ B7-2 monoclonal antibody

Anti-CD86/ FUN1/ B7-2 antibody for FACS & in-vivo assay

Target products collectionGo to FUN1/CD86 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T50912-Ab-1/ GM-Tg-hg-T50912-Ab-2Anti-Human FUN1/CD86 monoclonal antibodyHuman
GM-Tg-rg-T50912-Ab-1/ GM-Tg-rg-T50912-Ab-2Anti-Rat FUN1/CD86 monoclonal antibodyRat
GM-Tg-mg-T50912-Ab-1/ GM-Tg-mg-T50912-Ab-2Anti-Mouse FUN1/CD86 monoclonal antibodyMouse
GM-Tg-cynog-T50912-Ab-1/ GM-Tg-cynog-T50912-Ab-2Anti-Cynomolgus/ Rhesus macaque FUN1/CD86 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T50912-Ab-1/ GM-Tg-felg-T50912-Ab-2Anti-Feline FUN1/CD86 monoclonal antibodyFeline
GM-Tg-cang-T50912-Ab-1/ GM-Tg-cang-T50912-Ab-2Anti-Canine FUN1/CD86 monoclonal antibodyCanine
GM-Tg-bovg-T50912-Ab-1/ GM-Tg-bovg-T50912-Ab-2Anti-Bovine FUN1/CD86 monoclonal antibodyBovine
GM-Tg-equg-T50912-Ab-1/ GM-Tg-equg-T50912-Ab-2Anti-Equine FUN1/CD86 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T50912-Ab-1/ GM-Tg-hg-T50912-Ab-2; GM-Tg-rg-T50912-Ab-1/ GM-Tg-rg-T50912-Ab-2;
GM-Tg-mg-T50912-Ab-1/ GM-Tg-mg-T50912-Ab-2; GM-Tg-cynog-T50912-Ab-1/ GM-Tg-cynog-T50912-Ab-2;
GM-Tg-felg-T50912-Ab-1/ GM-Tg-felg-T50912-Ab-2; GM-Tg-cang-T50912-Ab-1/ GM-Tg-cang-T50912-Ab-2;
GM-Tg-bovg-T50912-Ab-1/ GM-Tg-bovg-T50912-Ab-2; GM-Tg-equg-T50912-Ab-1/ GM-Tg-equg-T50912-Ab-2
Products NameAnti-FUN1/CD86 monoclonal antibody
Formatmab
Target NameFUN1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FUN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CD86/ FUN1/ B7-2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP004743human CD86 Lentivirus plasmid
    ORF Viral VectorvGMLP004743human CD86 Lentivirus particle
    ORF Viral VectorpGMLPm001943mouse Cd86 Lentivirus plasmid
    ORF Viral VectorvGMLPm001943mouse Cd86 Lentivirus particle


    Target information

    Target IDGM-T50912
    Target NameFUN1
    Gene ID942,12524,56822,714390,403764,493704,414345,100060767
    Gene Symbol and SynonymsB7,B7-2,B7.2,B70,Cd28l2,CD28LG2,CD86,CLS1,ETC-1,LAB72,Ly-58,Ly58,MB7,MB7-2,TS/A-2
    Uniprot AccessionP42081
    Uniprot Entry NameCD86_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000114013
    Target ClassificationTumor-associated antigen (TAA)

    The target: FUN1, gene name: CD86, also named as B7-2, B7.2, B70, CD28LG2, LAB72. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.