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Anti-ADRB3/ BETA3AR monoclonal antibody
Anti-ADRB3/ BETA3AR antibody for FACS & in-vivo assay
Go to ADRB3/ADRB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51408-Ab-1/ GM-Tg-hg-T51408-Ab-2 | Anti-Human ADRB3 monoclonal antibody | Human |
| GM-Tg-rg-T51408-Ab-1/ GM-Tg-rg-T51408-Ab-2 | Anti-Rat ADRB3 monoclonal antibody | Rat |
| GM-Tg-mg-T51408-Ab-1/ GM-Tg-mg-T51408-Ab-2 | Anti-Mouse ADRB3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T51408-Ab-1/ GM-Tg-cynog-T51408-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADRB3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51408-Ab-1/ GM-Tg-felg-T51408-Ab-2 | Anti-Feline ADRB3 monoclonal antibody | Feline |
| GM-Tg-cang-T51408-Ab-1/ GM-Tg-cang-T51408-Ab-2 | Anti-Canine ADRB3 monoclonal antibody | Canine |
| GM-Tg-bovg-T51408-Ab-1/ GM-Tg-bovg-T51408-Ab-2 | Anti-Bovine ADRB3 monoclonal antibody | Bovine |
| GM-Tg-equg-T51408-Ab-1/ GM-Tg-equg-T51408-Ab-2 | Anti-Equine ADRB3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51408-Ab-1/ GM-Tg-hg-T51408-Ab-2; GM-Tg-rg-T51408-Ab-1/ GM-Tg-rg-T51408-Ab-2; GM-Tg-mg-T51408-Ab-1/ GM-Tg-mg-T51408-Ab-2; GM-Tg-cynog-T51408-Ab-1/ GM-Tg-cynog-T51408-Ab-2; GM-Tg-felg-T51408-Ab-1/ GM-Tg-felg-T51408-Ab-2; GM-Tg-cang-T51408-Ab-1/ GM-Tg-cang-T51408-Ab-2; GM-Tg-bovg-T51408-Ab-1/ GM-Tg-bovg-T51408-Ab-2; GM-Tg-equg-T51408-Ab-1/ GM-Tg-equg-T51408-Ab-2 |
| Products Name | Anti-ADRB3 monoclonal antibody |
| Format | mab |
| Target Name | ADRB3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ADRB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ADRB3/ BETA3AR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000001 | human ADRB3 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000001 | human ADRB3 Adenovirus particle |
| ORF Viral Vector | pGMLPm001753 | mouse Adrb3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001753 | mouse Adrb3 Lentivirus particle |
Target information
| Target ID | GM-T51408 |
| Target Name | ADRB3 |
| Gene ID | 155,11556,25645,699129,442979,493930,281606,100147322 |
| Gene Symbol and Synonyms | ADRB,Adrb-3,ADRB3,B3AR,BAR3,beta 3-AR,BETA3AR,GPCR |
| Uniprot Accession | P13945,P26255,Q28524,O02662,Q9TST4,P46626 |
| Uniprot Entry Name | ADRB3_HUMAN,ADRB3_MACMU,ADRB3_RAT,ADRB3_FELCA,ADRB3_CANLF,ADRB3_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000188778 |
| Target Classification | GPCR |
The target: ADRB3, gene name: ADRB3, also named as BETA3AR. The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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