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Anti-NFKBIA monoclonal antibody
Pre-made anti-NFKBIA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to NFKBIA/NFKBIA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51672-Ab-1/ GM-Tg-hg-T51672-Ab-2 | Anti-Human NFKBIA monoclonal antibody | Human |
| GM-Tg-rg-T51672-Ab-1/ GM-Tg-rg-T51672-Ab-2 | Anti-Rat NFKBIA monoclonal antibody | Rat |
| GM-Tg-mg-T51672-Ab-1/ GM-Tg-mg-T51672-Ab-2 | Anti-Mouse NFKBIA monoclonal antibody | Mouse |
| GM-Tg-cynog-T51672-Ab-1/ GM-Tg-cynog-T51672-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NFKBIA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51672-Ab-1/ GM-Tg-felg-T51672-Ab-2 | Anti-Feline NFKBIA monoclonal antibody | Feline |
| GM-Tg-cang-T51672-Ab-1/ GM-Tg-cang-T51672-Ab-2 | Anti-Canine NFKBIA monoclonal antibody | Canine |
| GM-Tg-bovg-T51672-Ab-1/ GM-Tg-bovg-T51672-Ab-2 | Anti-Bovine NFKBIA monoclonal antibody | Bovine |
| GM-Tg-equg-T51672-Ab-1/ GM-Tg-equg-T51672-Ab-2 | Anti-Equine NFKBIA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51672-Ab-1/ GM-Tg-hg-T51672-Ab-2; GM-Tg-rg-T51672-Ab-1/ GM-Tg-rg-T51672-Ab-2; GM-Tg-mg-T51672-Ab-1/ GM-Tg-mg-T51672-Ab-2; GM-Tg-cynog-T51672-Ab-1/ GM-Tg-cynog-T51672-Ab-2; GM-Tg-felg-T51672-Ab-1/ GM-Tg-felg-T51672-Ab-2; GM-Tg-cang-T51672-Ab-1/ GM-Tg-cang-T51672-Ab-2; GM-Tg-bovg-T51672-Ab-1/ GM-Tg-bovg-T51672-Ab-2; GM-Tg-equg-T51672-Ab-1/ GM-Tg-equg-T51672-Ab-2 |
| Products Name | Anti-NFKBIA monoclonal antibody |
| Format | mab |
| Target Name | NFKBIA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-NFKBIA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T51672-Ag-1 | Recombinant multi-species IKBA/ NFKBIA/ MAD-3 protein |
| ORF Viral Vector | pGMAP000119 | Human NFKBIA Adenovirus plasmid |
| ORF Viral Vector | pGMLV000540 | human NFKBIA Lentivirus plasmid |
| ORF Viral Vector | vGMLV000540 | human NFKBIA Lentivirus particle |
| ORF Viral Vector | vGMAP000119 | Human NFKBIA Adenovirus particle |
| ORF Viral Vector | pGMAD000047 | rat Nfkbia Adenovirus plasmid |
| ORF Viral Vector | pGMLPm003911 | mouse Nfkbia Lentivirus plasmid |
| ORF Viral Vector | vGMAD000047 | rat Nfkbia Adenovirus particle |
| ORF Viral Vector | vGMLPm003911 | mouse Nfkbia Lentivirus particle |
Target information
| Target ID | GM-T51672 |
| Target Name | NFKBIA |
| Gene ID | 4792,18035,25493,695335,480291,101090622,282291,100058000 |
| Gene Symbol and Synonyms | EDAID2,IKBA,MAD-3,NFKBI,NFKBIA,RL/IF-1 |
| Uniprot Accession | P25963,Q63746 |
| Uniprot Entry Name | IKBA_HUMAN,IKBA_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000100906 |
| Target Classification | Pathway |
The target: NFKBIA, gene name: NFKBIA, also named as IKBA, MAD-3, NFKBI. This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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