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Anti-PPAR-gamma monoclonal antibody
Pre-made anti-PPAR-gamma monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PPAR-gamma/PPARG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T58921-Ab-1/ GM-Tg-hg-T58921-Ab-2 | Anti-Human PPAR-gamma/PPARG monoclonal antibody | Human |
| GM-Tg-rg-T58921-Ab-1/ GM-Tg-rg-T58921-Ab-2 | Anti-Rat PPAR-gamma/PPARG monoclonal antibody | Rat |
| GM-Tg-mg-T58921-Ab-1/ GM-Tg-mg-T58921-Ab-2 | Anti-Mouse PPAR-gamma/PPARG monoclonal antibody | Mouse |
| GM-Tg-cynog-T58921-Ab-1/ GM-Tg-cynog-T58921-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPAR-gamma/PPARG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T58921-Ab-1/ GM-Tg-felg-T58921-Ab-2 | Anti-Feline PPAR-gamma/PPARG monoclonal antibody | Feline |
| GM-Tg-cang-T58921-Ab-1/ GM-Tg-cang-T58921-Ab-2 | Anti-Canine PPAR-gamma/PPARG monoclonal antibody | Canine |
| GM-Tg-bovg-T58921-Ab-1/ GM-Tg-bovg-T58921-Ab-2 | Anti-Bovine PPAR-gamma/PPARG monoclonal antibody | Bovine |
| GM-Tg-equg-T58921-Ab-1/ GM-Tg-equg-T58921-Ab-2 | Anti-Equine PPAR-gamma/PPARG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T58921-Ab-1/ GM-Tg-hg-T58921-Ab-2; GM-Tg-rg-T58921-Ab-1/ GM-Tg-rg-T58921-Ab-2; GM-Tg-mg-T58921-Ab-1/ GM-Tg-mg-T58921-Ab-2; GM-Tg-cynog-T58921-Ab-1/ GM-Tg-cynog-T58921-Ab-2; GM-Tg-felg-T58921-Ab-1/ GM-Tg-felg-T58921-Ab-2; GM-Tg-cang-T58921-Ab-1/ GM-Tg-cang-T58921-Ab-2; GM-Tg-bovg-T58921-Ab-1/ GM-Tg-bovg-T58921-Ab-2; GM-Tg-equg-T58921-Ab-1/ GM-Tg-equg-T58921-Ab-2 |
| Products Name | Anti-PPAR-gamma/PPARG monoclonal antibody |
| Format | mab |
| Target Name | PPAR-gamma |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PPAR-gamma monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T58921 |
| Target Name | PPAR-gamma |
| Gene ID | 5468,19016,25664,574190,403606,101095161,281993,100051258 |
| Gene Symbol and Synonyms | CIMT1,GLM1,NR1C3,PPAR-gamma,PPAR-gamma2,PPARG,PPARG1,PPARG2,PPARG5,PPARgamma,PPARgamma2 |
| Uniprot Accession | P37231,O88275,O18924,Q4U3Q4,O18971 |
| Uniprot Entry Name | PPARG_HUMAN,PPARG_MACMU,PPARG_RAT,PPARG_CANLF,PPARG_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000132170 |
| Target Classification | Nuclear Receptors, Tumor-associated antigen (TAA) |
The target: PPAR-gamma, gene name: PPARG, also named as CIMT1, GLM1, NR1C31, PPARG2, PPARgamma, PPARG. This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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