Anti-CO5/ C5/ C5Da functional antibody
Anti-CO5/ C5/ C5Da functional antibody for cell culture, ELISA & in-vivo assay
Go to CO5/C5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T60708-Ab-1/ GM-Tg-hg-T60708-Ab-2 | Anti-Human CO5/C5 monoclonal antibody | Human |
GM-Tg-rg-T60708-Ab-1/ GM-Tg-rg-T60708-Ab-2 | Anti-Rat CO5/C5 monoclonal antibody | Rat |
GM-Tg-mg-T60708-Ab-1/ GM-Tg-mg-T60708-Ab-2 | Anti-Mouse CO5/C5 monoclonal antibody | Mouse |
GM-Tg-cynog-T60708-Ab-1/ GM-Tg-cynog-T60708-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CO5/C5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T60708-Ab-1/ GM-Tg-felg-T60708-Ab-2 | Anti-Feline CO5/C5 monoclonal antibody | Feline |
GM-Tg-cang-T60708-Ab-1/ GM-Tg-cang-T60708-Ab-2 | Anti-Canine CO5/C5 monoclonal antibody | Canine |
GM-Tg-bovg-T60708-Ab-1/ GM-Tg-bovg-T60708-Ab-2 | Anti-Bovine CO5/C5 monoclonal antibody | Bovine |
GM-Tg-equg-T60708-Ab-1/ GM-Tg-equg-T60708-Ab-2 | Anti-Equine CO5/C5 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T60708-Ab-1/ GM-Tg-hg-T60708-Ab-2; GM-Tg-rg-T60708-Ab-1/ GM-Tg-rg-T60708-Ab-2; GM-Tg-mg-T60708-Ab-1/ GM-Tg-mg-T60708-Ab-2; GM-Tg-cynog-T60708-Ab-1/ GM-Tg-cynog-T60708-Ab-2; GM-Tg-felg-T60708-Ab-1/ GM-Tg-felg-T60708-Ab-2; GM-Tg-cang-T60708-Ab-1/ GM-Tg-cang-T60708-Ab-2; GM-Tg-bovg-T60708-Ab-1/ GM-Tg-bovg-T60708-Ab-2; GM-Tg-equg-T60708-Ab-1/ GM-Tg-equg-T60708-Ab-2 |
Products Name | Anti-CO5/C5 monoclonal antibody |
Format | mab |
Target Name | CO5 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-CO5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
Target ID | GM-T60708 |
Target Name | CO5 |
Gene ID | 727,15139,362119,700467,474816,101090401,512045,100067655 |
Gene Symbol and Synonyms | C5,C5a,C5b,C5D,CPAMD4,ECLZB,Hc,He,Hfib2,RGD1561905 |
Uniprot Accession | P01031,P08650,P12082 |
Uniprot Entry Name | CO5_HUMAN,CO5_RAT,CO5_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target, INN Index |
Disease | N/A |
Gene Ensembl | ENSG00000106804 |
Target Classification | N/A |
The target: CO5, gene name: C5, also named as C5Da, C5b, CPAMD4, ECLZB, C5. This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.