Anti-ADRBK1 monoclonal antibody
Pre-made anti-ADRBK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T62548-Ab-1/ GM-Tg-hg-T62548-Ab-2 | Anti-Human ADRBK1/GRK2 monoclonal antibody | Human |
GM-Tg-rg-T62548-Ab-1/ GM-Tg-rg-T62548-Ab-2 | Anti-Rat ADRBK1/GRK2 monoclonal antibody | Rat |
GM-Tg-mg-T62548-Ab-1/ GM-Tg-mg-T62548-Ab-2 | Anti-Mouse ADRBK1/GRK2 monoclonal antibody | Mouse |
GM-Tg-cynog-T62548-Ab-1/ GM-Tg-cynog-T62548-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADRBK1/GRK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T62548-Ab-1/ GM-Tg-felg-T62548-Ab-2 | Anti-Feline ADRBK1/GRK2 monoclonal antibody | Feline |
GM-Tg-cang-T62548-Ab-1/ GM-Tg-cang-T62548-Ab-2 | Anti-Canine ADRBK1/GRK2 monoclonal antibody | Canine |
GM-Tg-bovg-T62548-Ab-1/ GM-Tg-bovg-T62548-Ab-2 | Anti-Bovine ADRBK1/GRK2 monoclonal antibody | Bovine |
GM-Tg-equg-T62548-Ab-1/ GM-Tg-equg-T62548-Ab-2 | Anti-Equine ADRBK1/GRK2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T62548-Ab-1/ GM-Tg-hg-T62548-Ab-2; GM-Tg-rg-T62548-Ab-1/ GM-Tg-rg-T62548-Ab-2; GM-Tg-mg-T62548-Ab-1/ GM-Tg-mg-T62548-Ab-2; GM-Tg-cynog-T62548-Ab-1/ GM-Tg-cynog-T62548-Ab-2; GM-Tg-felg-T62548-Ab-1/ GM-Tg-felg-T62548-Ab-2; GM-Tg-cang-T62548-Ab-1/ GM-Tg-cang-T62548-Ab-2; GM-Tg-bovg-T62548-Ab-1/ GM-Tg-bovg-T62548-Ab-2; GM-Tg-equg-T62548-Ab-1/ GM-Tg-equg-T62548-Ab-2 |
Products Name | Anti-ADRBK1/GRK2 monoclonal antibody |
Format | mab |
Target Name | ADRBK1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-ADRBK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T62548-Ag-1 | Recombinant multi-species ARBK1/ ADRBK1/ GRK2 protein |
ORF Viral Vector | pGMLP001657 | human GRK2 Lentivirus plasmid |
ORF Viral Vector | vGMLV000648 | human GRK2 Lentivirus particle |
ORF Viral Vector | vGMLP001657 | human GRK2 Lentivirus particle |
ORF Viral Vector | pGMLV000648 | human GRK2 Lentivirus plasmid |
ORF Viral Vector | pGMAD000099 | pig GRK2 Adenovirus plasmid |
ORF Viral Vector | pGMAAV000240 | Norway rat Grk2 AAV plasmid |
ORF Viral Vector | vGMAD000099 | pig GRK2 Adenovirus particle |
ORF Viral Vector | vGMAAV000240 | Norway rat Grk2 AAV particle |
Target information
Target ID | GM-T62548 |
Target Name | ADRBK1 |
Gene ID | 156,110355,25238,721754,483701,101101082,282682,100059001 |
Gene Symbol and Synonyms | Adrbk-1,ADRBK1,Bark-1,BARK1,beta ARK,BETA-ARK1,betaARK1,GRK-2,GRK2 |
Uniprot Accession | P25098,P26817,P21146 |
Uniprot Entry Name | ARBK1_HUMAN,ARBK1_RAT,ARBK1_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000173020 |
Target Classification | Kinase |
The target: ADRBK1, gene name: GRK2, also named as ADRBK1, BARK1, BETA-ARK1. This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.