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Anti-p38 alpha monoclonal antibody
Pre-made anti-p38 alpha monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to p38 alpha/MAPK14 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T65864-Ab-1/ GM-Tg-hg-T65864-Ab-2 | Anti-Human p38 alpha/MAPK14 monoclonal antibody | Human |
| GM-Tg-rg-T65864-Ab-1/ GM-Tg-rg-T65864-Ab-2 | Anti-Rat p38 alpha/MAPK14 monoclonal antibody | Rat |
| GM-Tg-mg-T65864-Ab-1/ GM-Tg-mg-T65864-Ab-2 | Anti-Mouse p38 alpha/MAPK14 monoclonal antibody | Mouse |
| GM-Tg-cynog-T65864-Ab-1/ GM-Tg-cynog-T65864-Ab-2 | Anti-Cynomolgus/ Rhesus macaque p38 alpha/MAPK14 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T65864-Ab-1/ GM-Tg-felg-T65864-Ab-2 | Anti-Feline p38 alpha/MAPK14 monoclonal antibody | Feline |
| GM-Tg-cang-T65864-Ab-1/ GM-Tg-cang-T65864-Ab-2 | Anti-Canine p38 alpha/MAPK14 monoclonal antibody | Canine |
| GM-Tg-bovg-T65864-Ab-1/ GM-Tg-bovg-T65864-Ab-2 | Anti-Bovine p38 alpha/MAPK14 monoclonal antibody | Bovine |
| GM-Tg-equg-T65864-Ab-1/ GM-Tg-equg-T65864-Ab-2 | Anti-Equine p38 alpha/MAPK14 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T65864-Ab-1/ GM-Tg-hg-T65864-Ab-2; GM-Tg-rg-T65864-Ab-1/ GM-Tg-rg-T65864-Ab-2; GM-Tg-mg-T65864-Ab-1/ GM-Tg-mg-T65864-Ab-2; GM-Tg-cynog-T65864-Ab-1/ GM-Tg-cynog-T65864-Ab-2; GM-Tg-felg-T65864-Ab-1/ GM-Tg-felg-T65864-Ab-2; GM-Tg-cang-T65864-Ab-1/ GM-Tg-cang-T65864-Ab-2; GM-Tg-bovg-T65864-Ab-1/ GM-Tg-bovg-T65864-Ab-2; GM-Tg-equg-T65864-Ab-1/ GM-Tg-equg-T65864-Ab-2 |
| Products Name | Anti-p38 alpha/MAPK14 monoclonal antibody |
| Format | mab |
| Target Name | p38 alpha |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-p38 alpha monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T65864-Ag-1 | Recombinant multi-species MK14/ p38 alpha/ MAPK14 protein |
| ORF Viral Vector | vGMAD000565 | human MAPK14 Adenovirus particle |
| ORF Viral Vector | pGMAP000408 | Human MAPK14 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000565 | human MAPK14 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000408 | Human MAPK14 Adenovirus particle |
Target information
| Target ID | GM-T65864 |
| Target Name | p38 alpha |
| Gene ID | 1432,26416,81649,718976,403856,101101135,534492,100063532 |
| Gene Symbol and Synonyms | Crk1,CSBP,CSBP1,CSBP2,CSPB1,EXIP,Hog,MAPK14,Mxi2,p38,p38-alpha,p38a,p38ALPHA,p38Hog,p38MAPK,PRKM14,PRKM15,RK,SAPK2A |
| Uniprot Accession | Q16539,P70618,O02812 |
| Uniprot Entry Name | MK14_HUMAN,MK14_RAT,MK14_CANLF |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000112062 |
| Target Classification | Checkpoint-Immuno Oncology, Kinase |
The target: p38 alpha, gene name: MAPK14, also named as CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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