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Anti-TLR3/ CD283/ IIAE2 functional antibody
Anti-TLR3/ CD283/ IIAE2 functional antibody for cell culture, ELISA & in-vivo assay
Go to TLR3/TLR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T67894-Ab-1/ GM-Tg-hg-T67894-Ab-2 | Anti-Human TLR3 monoclonal antibody | Human |
| GM-Tg-rg-T67894-Ab-1/ GM-Tg-rg-T67894-Ab-2 | Anti-Rat TLR3 monoclonal antibody | Rat |
| GM-Tg-mg-T67894-Ab-1/ GM-Tg-mg-T67894-Ab-2 | Anti-Mouse TLR3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T67894-Ab-1/ GM-Tg-cynog-T67894-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TLR3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T67894-Ab-1/ GM-Tg-felg-T67894-Ab-2 | Anti-Feline TLR3 monoclonal antibody | Feline |
| GM-Tg-cang-T67894-Ab-1/ GM-Tg-cang-T67894-Ab-2 | Anti-Canine TLR3 monoclonal antibody | Canine |
| GM-Tg-bovg-T67894-Ab-1/ GM-Tg-bovg-T67894-Ab-2 | Anti-Bovine TLR3 monoclonal antibody | Bovine |
| GM-Tg-equg-T67894-Ab-1/ GM-Tg-equg-T67894-Ab-2 | Anti-Equine TLR3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T67894-Ab-1/ GM-Tg-hg-T67894-Ab-2; GM-Tg-rg-T67894-Ab-1/ GM-Tg-rg-T67894-Ab-2; GM-Tg-mg-T67894-Ab-1/ GM-Tg-mg-T67894-Ab-2; GM-Tg-cynog-T67894-Ab-1/ GM-Tg-cynog-T67894-Ab-2; GM-Tg-felg-T67894-Ab-1/ GM-Tg-felg-T67894-Ab-2; GM-Tg-cang-T67894-Ab-1/ GM-Tg-cang-T67894-Ab-2; GM-Tg-bovg-T67894-Ab-1/ GM-Tg-bovg-T67894-Ab-2; GM-Tg-equg-T67894-Ab-1/ GM-Tg-equg-T67894-Ab-2 |
| Products Name | Anti-TLR3 monoclonal antibody |
| Format | mab |
| Target Name | TLR3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TLR3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T67894-Ag-1 | Recombinant multi-species TLR3/ CD283/ IIAE2 protein |
Target information
| Target ID | GM-T67894 |
| Target Name | TLR3 |
| Gene ID | 7098,142980,364594,574378,482905,493661,281535,100009703 |
| Gene Symbol and Synonyms | CD283,IIAE2,IMD83,TLR3 |
| Uniprot Accession | O15455,Q5TJ59 |
| Uniprot Entry Name | TLR3_HUMAN,TLR3_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000164342 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: TLR3, gene name: TLR3, also named as CD283, IIAE2. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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