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Anti-RTN4/ ASY/ NI220/250 monoclonal antibody
Anti-RTN4/ ASY/ NI220/250 antibody for FACS & in-vivo assay
Go to RTN4/RTN4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T72236-Ab-1/ GM-Tg-hg-T72236-Ab-2 | Anti-Human RTN4 monoclonal antibody | Human |
| GM-Tg-rg-T72236-Ab-1/ GM-Tg-rg-T72236-Ab-2 | Anti-Rat RTN4 monoclonal antibody | Rat |
| GM-Tg-mg-T72236-Ab-1/ GM-Tg-mg-T72236-Ab-2 | Anti-Mouse RTN4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T72236-Ab-1/ GM-Tg-cynog-T72236-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RTN4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T72236-Ab-1/ GM-Tg-felg-T72236-Ab-2 | Anti-Feline RTN4 monoclonal antibody | Feline |
| GM-Tg-cang-T72236-Ab-1/ GM-Tg-cang-T72236-Ab-2 | Anti-Canine RTN4 monoclonal antibody | Canine |
| GM-Tg-bovg-T72236-Ab-1/ GM-Tg-bovg-T72236-Ab-2 | Anti-Bovine RTN4 monoclonal antibody | Bovine |
| GM-Tg-equg-T72236-Ab-1/ GM-Tg-equg-T72236-Ab-2 | Anti-Equine RTN4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T72236-Ab-1/ GM-Tg-hg-T72236-Ab-2; GM-Tg-rg-T72236-Ab-1/ GM-Tg-rg-T72236-Ab-2; GM-Tg-mg-T72236-Ab-1/ GM-Tg-mg-T72236-Ab-2; GM-Tg-cynog-T72236-Ab-1/ GM-Tg-cynog-T72236-Ab-2; GM-Tg-felg-T72236-Ab-1/ GM-Tg-felg-T72236-Ab-2; GM-Tg-cang-T72236-Ab-1/ GM-Tg-cang-T72236-Ab-2; GM-Tg-bovg-T72236-Ab-1/ GM-Tg-bovg-T72236-Ab-2; GM-Tg-equg-T72236-Ab-1/ GM-Tg-equg-T72236-Ab-2 |
| Products Name | Anti-RTN4 monoclonal antibody |
| Format | mab |
| Target Name | RTN4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RTN4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RTN4/ ASY/ NI220/250 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002802 | human RTN4 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002802 | human RTN4 Lentivirus particle |
| ORF Viral Vector | pGMLV000586 | Norway rat Rtn4 Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000341 | house mouse Rtn4 AAV plasmid |
| ORF Viral Vector | vGMLV000586 | Norway rat Rtn4 Lentivirus particle |
| ORF Viral Vector | vGMAAV000341 | house mouse Rtn4 AAV particle |
Target information
| Target ID | GM-T72236 |
| Target Name | RTN4 |
| Gene ID | 57142,68585,83765,619181,474598,101091611,359718,100066612 |
| Gene Symbol and Synonyms | 1110020G17Rik,ASY,C130026I10Rik,mKIAA0886,mKIAA4153,Nbla00271,Nbla10545,NgA,NI-250,NI220/250,NOGO,Nogo-A,Nogo-B,Nogo-C,NSP,NSP-CL,rat N,rat NogoA,RTN-X,RTN4,RTN4-A,RTN4-B1,RTN4-B2,RTN4-C,RTN4-Cw,Vp20 |
| Uniprot Accession | Q9NQC3,Q9JK11 |
| Uniprot Entry Name | RTN4_HUMAN,RTN4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000115310 |
| Target Classification | N/A |
The target: RTN4, gene name: RTN4, also named as ASY, NI220/250, NOGO, NSP, NSP-CL, Nbla00271, Nbla10545, RTN-X-A, RTN4-B1, RTN4-B2, RTN4-C, RTN4. This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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