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Anti-ITCH monoclonal antibody
Pre-made anti-ITCH monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ITCH/ITCH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T81240-Ab-1/ GM-Tg-hg-T81240-Ab-2 | Anti-Human ITCH monoclonal antibody | Human |
| GM-Tg-rg-T81240-Ab-1/ GM-Tg-rg-T81240-Ab-2 | Anti-Rat ITCH monoclonal antibody | Rat |
| GM-Tg-mg-T81240-Ab-1/ GM-Tg-mg-T81240-Ab-2 | Anti-Mouse ITCH monoclonal antibody | Mouse |
| GM-Tg-cynog-T81240-Ab-1/ GM-Tg-cynog-T81240-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ITCH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T81240-Ab-1/ GM-Tg-felg-T81240-Ab-2 | Anti-Feline ITCH monoclonal antibody | Feline |
| GM-Tg-cang-T81240-Ab-1/ GM-Tg-cang-T81240-Ab-2 | Anti-Canine ITCH monoclonal antibody | Canine |
| GM-Tg-bovg-T81240-Ab-1/ GM-Tg-bovg-T81240-Ab-2 | Anti-Bovine ITCH monoclonal antibody | Bovine |
| GM-Tg-equg-T81240-Ab-1/ GM-Tg-equg-T81240-Ab-2 | Anti-Equine ITCH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T81240-Ab-1/ GM-Tg-hg-T81240-Ab-2; GM-Tg-rg-T81240-Ab-1/ GM-Tg-rg-T81240-Ab-2; GM-Tg-mg-T81240-Ab-1/ GM-Tg-mg-T81240-Ab-2; GM-Tg-cynog-T81240-Ab-1/ GM-Tg-cynog-T81240-Ab-2; GM-Tg-felg-T81240-Ab-1/ GM-Tg-felg-T81240-Ab-2; GM-Tg-cang-T81240-Ab-1/ GM-Tg-cang-T81240-Ab-2; GM-Tg-bovg-T81240-Ab-1/ GM-Tg-bovg-T81240-Ab-2; GM-Tg-equg-T81240-Ab-1/ GM-Tg-equg-T81240-Ab-2 |
| Products Name | Anti-ITCH monoclonal antibody |
| Format | mab |
| Target Name | ITCH |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ITCH monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T81240-Ag-1 | Recombinant multi-species ITCH/ ADMFD/ AIF4 protein |
| ORF Viral Vector | vGMLV000051 | human ITCH Lentivirus particle |
| ORF Viral Vector | pGMLV000051 | human ITCH Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003580 | mouse Itch Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003580 | mouse Itch Lentivirus particle |
Target information
| Target ID | GM-T81240 |
| Target Name | ITCH |
| Gene ID | 83737,16396,311567,707640,477199,101086133,508431,100069340 |
| Gene Symbol and Synonyms | 6720481N21Rik,8030492O04Rik,A130065M08,ADMFD,AIF4,AIP4,C230047C07Rik,ITCH,NAPP1 |
| Uniprot Accession | Q96J02 |
| Uniprot Entry Name | ITCH_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000078747 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ITCH, gene name: ITCH, also named as ADMFD, AIF4, AIP4, NAPP1. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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