Anti-IDE/ INSULYSIN functional antibody
Anti-IDE/ INSULYSIN functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T81900-Ab-1/ GM-Tg-hg-T81900-Ab-2 | Anti-Human IDE monoclonal antibody | Human |
GM-Tg-rg-T81900-Ab-1/ GM-Tg-rg-T81900-Ab-2 | Anti-Rat IDE monoclonal antibody | Rat |
GM-Tg-mg-T81900-Ab-1/ GM-Tg-mg-T81900-Ab-2 | Anti-Mouse IDE monoclonal antibody | Mouse |
GM-Tg-cynog-T81900-Ab-1/ GM-Tg-cynog-T81900-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IDE monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T81900-Ab-1/ GM-Tg-felg-T81900-Ab-2 | Anti-Feline IDE monoclonal antibody | Feline |
GM-Tg-cang-T81900-Ab-1/ GM-Tg-cang-T81900-Ab-2 | Anti-Canine IDE monoclonal antibody | Canine |
GM-Tg-bovg-T81900-Ab-1/ GM-Tg-bovg-T81900-Ab-2 | Anti-Bovine IDE monoclonal antibody | Bovine |
GM-Tg-equg-T81900-Ab-1/ GM-Tg-equg-T81900-Ab-2 | Anti-Equine IDE monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T81900-Ab-1/ GM-Tg-hg-T81900-Ab-2; GM-Tg-rg-T81900-Ab-1/ GM-Tg-rg-T81900-Ab-2; GM-Tg-mg-T81900-Ab-1/ GM-Tg-mg-T81900-Ab-2; GM-Tg-cynog-T81900-Ab-1/ GM-Tg-cynog-T81900-Ab-2; GM-Tg-felg-T81900-Ab-1/ GM-Tg-felg-T81900-Ab-2; GM-Tg-cang-T81900-Ab-1/ GM-Tg-cang-T81900-Ab-2; GM-Tg-bovg-T81900-Ab-1/ GM-Tg-bovg-T81900-Ab-2; GM-Tg-equg-T81900-Ab-1/ GM-Tg-equg-T81900-Ab-2 |
Products Name | Anti-IDE monoclonal antibody |
Format | mab |
Target Name | IDE |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-IDE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T81900-Ag-1 | Recombinant multi-species IDE/ INSULYSIN protein |
Target information
Target ID | GM-T81900 |
Target Name | IDE |
Gene ID | 3416,15925,25700,698640,477768,101093646,523752,100071303 |
Gene Symbol and Synonyms | 1300012G03Rik,4833415K22Rik,IDE,INSDEGM,INSULYSIN |
Uniprot Accession | P14735,P35559,Q24K02 |
Uniprot Entry Name | IDE_HUMAN,IDE_RAT,IDE_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000119912 |
Target Classification | N/A |
The target: IDE, gene name: IDE, also named as INSULYSIN. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.