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Anti-THIO/ TXN/ TRDX functional antibody
Anti-THIO/ TXN/ TRDX functional antibody for cell culture, ELISA & in-vivo assay
Go to TXN/TXN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T85616-Ab-1/ GM-Tg-hg-T85616-Ab-2 | Anti-Human TXN monoclonal antibody | Human |
| GM-Tg-rg-T85616-Ab-1/ GM-Tg-rg-T85616-Ab-2 | Anti-Rat TXN monoclonal antibody | Rat |
| GM-Tg-mg-T85616-Ab-1/ GM-Tg-mg-T85616-Ab-2 | Anti-Mouse TXN monoclonal antibody | Mouse |
| GM-Tg-cynog-T85616-Ab-1/ GM-Tg-cynog-T85616-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TXN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T85616-Ab-1/ GM-Tg-felg-T85616-Ab-2 | Anti-Feline TXN monoclonal antibody | Feline |
| GM-Tg-cang-T85616-Ab-1/ GM-Tg-cang-T85616-Ab-2 | Anti-Canine TXN monoclonal antibody | Canine |
| GM-Tg-bovg-T85616-Ab-1/ GM-Tg-bovg-T85616-Ab-2 | Anti-Bovine TXN monoclonal antibody | Bovine |
| GM-Tg-equg-T85616-Ab-1/ GM-Tg-equg-T85616-Ab-2 | Anti-Equine TXN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T85616-Ab-1/ GM-Tg-hg-T85616-Ab-2; GM-Tg-rg-T85616-Ab-1/ GM-Tg-rg-T85616-Ab-2; GM-Tg-mg-T85616-Ab-1/ GM-Tg-mg-T85616-Ab-2; GM-Tg-cynog-T85616-Ab-1/ GM-Tg-cynog-T85616-Ab-2; GM-Tg-felg-T85616-Ab-1/ GM-Tg-felg-T85616-Ab-2; GM-Tg-cang-T85616-Ab-1/ GM-Tg-cang-T85616-Ab-2; GM-Tg-bovg-T85616-Ab-1/ GM-Tg-bovg-T85616-Ab-2; GM-Tg-equg-T85616-Ab-1/ GM-Tg-equg-T85616-Ab-2 |
| Products Name | Anti-TXN monoclonal antibody |
| Format | mab |
| Target Name | TXN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TXN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T85616-Ag-1 | Recombinant multi-species THIO/ TXN/ TRDX protein |
| ORF Viral Vector | vGMAD000153 | human TXN Adenovirus particle |
| ORF Viral Vector | vGMLP000876 | human TXN Lentivirus particle |
| ORF Viral Vector | pGMAD000153 | human TXN Adenovirus plasmid |
| ORF Viral Vector | pGMLP000876 | human TXN Lentivirus plasmid |
| ORF Viral Vector | pGMAD000538 | Norway rat Txn1 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000207 | house mouse Txn1 AAV plasmid |
| ORF Viral Vector | pGMLPm002205 | mouse Txn1 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000538 | Norway rat Txn1 Adenovirus particle |
| ORF Viral Vector | vGMAAV000207 | house mouse Txn1 AAV particle |
| ORF Viral Vector | vGMLPm002205 | mouse Txn1 Lentivirus particle |
Target information
| Target ID | GM-T85616 |
| Target Name | TXN |
| Gene ID | 7295,22166,116484,712587,474798,101090655,280950,100033827 |
| Gene Symbol and Synonyms | ADF,TRDX,TRX,TRX1,Trx80,TXN,TXN1 |
| Uniprot Accession | P10599,P11232,P29451,P99505,O97680,O97508 |
| Uniprot Entry Name | THIO_HUMAN,THIO_MACMU,THIO_RAT,THIO_CANLF,THIO_BOVIN,THIO_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000136810 |
| Target Classification | N/A |
The target: TXN, gene name: TXN, also named as TRDX, TRX, TRX1. The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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