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Anti-DNMT1 monoclonal antibody
Pre-made anti-DNMT1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DNMT1/DNMT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T88304-Ab-1/ GM-Tg-hg-T88304-Ab-2 | Anti-Human DNMT1 monoclonal antibody | Human |
| GM-Tg-rg-T88304-Ab-1/ GM-Tg-rg-T88304-Ab-2 | Anti-Rat DNMT1 monoclonal antibody | Rat |
| GM-Tg-mg-T88304-Ab-1/ GM-Tg-mg-T88304-Ab-2 | Anti-Mouse DNMT1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T88304-Ab-1/ GM-Tg-cynog-T88304-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DNMT1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T88304-Ab-1/ GM-Tg-felg-T88304-Ab-2 | Anti-Feline DNMT1 monoclonal antibody | Feline |
| GM-Tg-cang-T88304-Ab-1/ GM-Tg-cang-T88304-Ab-2 | Anti-Canine DNMT1 monoclonal antibody | Canine |
| GM-Tg-bovg-T88304-Ab-1/ GM-Tg-bovg-T88304-Ab-2 | Anti-Bovine DNMT1 monoclonal antibody | Bovine |
| GM-Tg-equg-T88304-Ab-1/ GM-Tg-equg-T88304-Ab-2 | Anti-Equine DNMT1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T88304-Ab-1/ GM-Tg-hg-T88304-Ab-2; GM-Tg-rg-T88304-Ab-1/ GM-Tg-rg-T88304-Ab-2; GM-Tg-mg-T88304-Ab-1/ GM-Tg-mg-T88304-Ab-2; GM-Tg-cynog-T88304-Ab-1/ GM-Tg-cynog-T88304-Ab-2; GM-Tg-felg-T88304-Ab-1/ GM-Tg-felg-T88304-Ab-2; GM-Tg-cang-T88304-Ab-1/ GM-Tg-cang-T88304-Ab-2; GM-Tg-bovg-T88304-Ab-1/ GM-Tg-bovg-T88304-Ab-2; GM-Tg-equg-T88304-Ab-1/ GM-Tg-equg-T88304-Ab-2 |
| Products Name | Anti-DNMT1 monoclonal antibody |
| Format | mab |
| Target Name | DNMT1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DNMT1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T88304-Ag-1 | Recombinant multi-species DNMT1/ ADCADN/ AIM protein |
| ORF Viral Vector | vGMAD000065 | human DNMT1 Adenovirus particle |
| ORF Viral Vector | pGMAD000065 | human DNMT1 Adenovirus plasmid |
Target information
| Target ID | GM-T88304 |
| Target Name | DNMT1 |
| Gene ID | 1786,13433,84350,574321,476715,101093502,281119,100058341 |
| Gene Symbol and Synonyms | ADCADN,AIM,CXXC9,DNMT,DNMT1,Dnmt1o,HSN1E,m.HsaI,m.MmuI,MCMT,Met-1,Met1,MommeD2,MTase |
| Uniprot Accession | P26358,Q9Z330,Q24K09 |
| Uniprot Entry Name | DNMT1_HUMAN,DNMT1_RAT,DNMT1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000130816 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: DNMT1, gene name: DNMT1, also named as ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI. This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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