Anti-LRP1/ LRP-1/ A2MR monoclonal antibody

Anti-LRP1/ LRP-1/ A2MR antibody for FACS & in-vivo assay

Target products collectionGo to LRP-1/LRP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T91130-Ab-1/ GM-Tg-hg-T91130-Ab-2Anti-Human LRP-1/LRP1 monoclonal antibodyHuman
GM-Tg-rg-T91130-Ab-1/ GM-Tg-rg-T91130-Ab-2Anti-Rat LRP-1/LRP1 monoclonal antibodyRat
GM-Tg-mg-T91130-Ab-1/ GM-Tg-mg-T91130-Ab-2Anti-Mouse LRP-1/LRP1 monoclonal antibodyMouse
GM-Tg-cynog-T91130-Ab-1/ GM-Tg-cynog-T91130-Ab-2Anti-Cynomolgus/ Rhesus macaque LRP-1/LRP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T91130-Ab-1/ GM-Tg-felg-T91130-Ab-2Anti-Feline LRP-1/LRP1 monoclonal antibodyFeline
GM-Tg-cang-T91130-Ab-1/ GM-Tg-cang-T91130-Ab-2Anti-Canine LRP-1/LRP1 monoclonal antibodyCanine
GM-Tg-bovg-T91130-Ab-1/ GM-Tg-bovg-T91130-Ab-2Anti-Bovine LRP-1/LRP1 monoclonal antibodyBovine
GM-Tg-equg-T91130-Ab-1/ GM-Tg-equg-T91130-Ab-2Anti-Equine LRP-1/LRP1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T91130-Ab-1/ GM-Tg-hg-T91130-Ab-2; GM-Tg-rg-T91130-Ab-1/ GM-Tg-rg-T91130-Ab-2;
GM-Tg-mg-T91130-Ab-1/ GM-Tg-mg-T91130-Ab-2; GM-Tg-cynog-T91130-Ab-1/ GM-Tg-cynog-T91130-Ab-2;
GM-Tg-felg-T91130-Ab-1/ GM-Tg-felg-T91130-Ab-2; GM-Tg-cang-T91130-Ab-1/ GM-Tg-cang-T91130-Ab-2;
GM-Tg-bovg-T91130-Ab-1/ GM-Tg-bovg-T91130-Ab-2; GM-Tg-equg-T91130-Ab-1/ GM-Tg-equg-T91130-Ab-2
Products NameAnti-LRP-1/LRP1 monoclonal antibody
Formatmab
Target NameLRP-1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRP-1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRP1/ LRP-1/ A2MR VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAP000292Human LRP1 Adenovirus plasmid
    ORF Viral VectorvGMAP000292Human LRP1 Adenovirus particle


    Target information

    Target IDGM-T91130
    Target NameLRP-1
    Gene ID4035,16971,299858,710965,481124,101090780,533894,100052936
    Gene Symbol and SynonymsA2MR,APOER,APR,b2b1554Clo,CD91,IGFBP-3R,IGFBP3R,IGFBP3R1,KPA,LRP,LRP-1,LRP1,LRP1A,TGFBR5
    Uniprot AccessionQ07954,G3V928
    Uniprot Entry NameLRP1_HUMAN,LRP1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000123384
    Target ClassificationTumor-associated antigen (TAA)

    The target: LRP-1, gene name: LRP1, also named as A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRPA, TGFBR5, LRP1. This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.