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Anti-IL24/ C49A/ FISP functional antibody
Anti-IL24/ C49A/ FISP functional antibody for cell culture, ELISA & in-vivo assay
Go to IL24/IL24 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T93450-Ab-1/ GM-Tg-hg-T93450-Ab-2 | Anti-Human IL24 monoclonal antibody | Human |
| GM-Tg-rg-T93450-Ab-1/ GM-Tg-rg-T93450-Ab-2 | Anti-Rat IL24 monoclonal antibody | Rat |
| GM-Tg-mg-T93450-Ab-1/ GM-Tg-mg-T93450-Ab-2 | Anti-Mouse IL24 monoclonal antibody | Mouse |
| GM-Tg-cynog-T93450-Ab-1/ GM-Tg-cynog-T93450-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL24 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T93450-Ab-1/ GM-Tg-felg-T93450-Ab-2 | Anti-Feline IL24 monoclonal antibody | Feline |
| GM-Tg-cang-T93450-Ab-1/ GM-Tg-cang-T93450-Ab-2 | Anti-Canine IL24 monoclonal antibody | Canine |
| GM-Tg-bovg-T93450-Ab-1/ GM-Tg-bovg-T93450-Ab-2 | Anti-Bovine IL24 monoclonal antibody | Bovine |
| GM-Tg-equg-T93450-Ab-1/ GM-Tg-equg-T93450-Ab-2 | Anti-Equine IL24 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T93450-Ab-1/ GM-Tg-hg-T93450-Ab-2; GM-Tg-rg-T93450-Ab-1/ GM-Tg-rg-T93450-Ab-2; GM-Tg-mg-T93450-Ab-1/ GM-Tg-mg-T93450-Ab-2; GM-Tg-cynog-T93450-Ab-1/ GM-Tg-cynog-T93450-Ab-2; GM-Tg-felg-T93450-Ab-1/ GM-Tg-felg-T93450-Ab-2; GM-Tg-cang-T93450-Ab-1/ GM-Tg-cang-T93450-Ab-2; GM-Tg-bovg-T93450-Ab-1/ GM-Tg-bovg-T93450-Ab-2; GM-Tg-equg-T93450-Ab-1/ GM-Tg-equg-T93450-Ab-2 |
| Products Name | Anti-IL24 monoclonal antibody |
| Format | mab |
| Target Name | IL24 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL24 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T93450-Ag-1 | Recombinant multi-species IL24/ C49A/ FISP protein |
| Cytokine | GM-Tg-g-T93450-Ag-1 | interleukin 24 (IL24) protein |
| ORF Viral Vector | pGMLV000181 | human IL24 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000195 | human IL24 Adenovirus particle |
| ORF Viral Vector | pGMAD000195 | human IL24 Adenovirus plasmid |
| ORF Viral Vector | vGMLV000181 | human IL24 Lentivirus particle |
Target information
| Target ID | GM-T93450 |
| Target Name | IL24 |
| Gene ID | 11009,93672,170819,694541,609213,101095874,526285,100055675 |
| Gene Symbol and Synonyms | C49A,FISP,If2e,IL10B,IL24,Mda-7,MDA7,MOB5,ST16 |
| Uniprot Accession | Q13007,Q9JI24 |
| Uniprot Entry Name | IL24_HUMAN,IL24_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000162892 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: IL24, gene name: IL24, also named as C49A, FISP, IL10B, MDA7, MOB5, ST16. This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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