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Anti-S6K1 monoclonal antibody
Pre-made anti-S6K1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to S6K1/RPS6KB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T94479-Ab-1/ GM-Tg-hg-T94479-Ab-2 | Anti-Human S6K1/RPS6KB1 monoclonal antibody | Human |
| GM-Tg-rg-T94479-Ab-1/ GM-Tg-rg-T94479-Ab-2 | Anti-Rat S6K1/RPS6KB1 monoclonal antibody | Rat |
| GM-Tg-mg-T94479-Ab-1/ GM-Tg-mg-T94479-Ab-2 | Anti-Mouse S6K1/RPS6KB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T94479-Ab-1/ GM-Tg-cynog-T94479-Ab-2 | Anti-Cynomolgus/ Rhesus macaque S6K1/RPS6KB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T94479-Ab-1/ GM-Tg-felg-T94479-Ab-2 | Anti-Feline S6K1/RPS6KB1 monoclonal antibody | Feline |
| GM-Tg-cang-T94479-Ab-1/ GM-Tg-cang-T94479-Ab-2 | Anti-Canine S6K1/RPS6KB1 monoclonal antibody | Canine |
| GM-Tg-bovg-T94479-Ab-1/ GM-Tg-bovg-T94479-Ab-2 | Anti-Bovine S6K1/RPS6KB1 monoclonal antibody | Bovine |
| GM-Tg-equg-T94479-Ab-1/ GM-Tg-equg-T94479-Ab-2 | Anti-Equine S6K1/RPS6KB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T94479-Ab-1/ GM-Tg-hg-T94479-Ab-2; GM-Tg-rg-T94479-Ab-1/ GM-Tg-rg-T94479-Ab-2; GM-Tg-mg-T94479-Ab-1/ GM-Tg-mg-T94479-Ab-2; GM-Tg-cynog-T94479-Ab-1/ GM-Tg-cynog-T94479-Ab-2; GM-Tg-felg-T94479-Ab-1/ GM-Tg-felg-T94479-Ab-2; GM-Tg-cang-T94479-Ab-1/ GM-Tg-cang-T94479-Ab-2; GM-Tg-bovg-T94479-Ab-1/ GM-Tg-bovg-T94479-Ab-2; GM-Tg-equg-T94479-Ab-1/ GM-Tg-equg-T94479-Ab-2 |
| Products Name | Anti-S6K1/RPS6KB1 monoclonal antibody |
| Format | mab |
| Target Name | S6K1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-S6K1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T94479-Ag-1 | Recombinant multi-species KS6B1/ S6K1/ RPS6KB1 protein |
| ORF Viral Vector | pGMLP001423 | human RPS6KB1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001423 | human RPS6KB1 Lentivirus particle |
| ORF Viral Vector | pGMLPm002997 | mouse Rps6kb1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002997 | mouse Rps6kb1 Lentivirus particle |
Target information
| Target ID | GM-T94479 |
| Target Name | S6K1 |
| Gene ID | 6198,72508,83840,711979,480580,101092561,404181,100057481 |
| Gene Symbol and Synonyms | 2610318I15Rik,p70 S6K-alpha,p70 S6KA,p70(S6K)-alpha,p70-alpha,p70-S6K,p70-S6K 1,p70/85s6k,p70s6k,P70S6K1,PS6K,RPS6KB1,S6K,S6K-beta-1,S6K1,STK14A |
| Uniprot Accession | P23443,P67999,Q6TJY3 |
| Uniprot Entry Name | KS6B1_HUMAN,KS6B1_RAT,KS6B1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000108443 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: S6K1, gene name: RPS6KB1, also named as PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha. This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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