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Anti-GUC2C/ GUCY2C/ DIAR6 monoclonal antibody
Anti-GUC2C/ GUCY2C/ DIAR6 antibody for FACS & in-vivo assay
Go to GUCY2C/GUCY2C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T97947-Ab-1/ GM-Tg-hg-T97947-Ab-2 | Anti-Human GUCY2C monoclonal antibody | Human |
| GM-Tg-rg-T97947-Ab-1/ GM-Tg-rg-T97947-Ab-2 | Anti-Rat GUCY2C monoclonal antibody | Rat |
| GM-Tg-mg-T97947-Ab-1/ GM-Tg-mg-T97947-Ab-2 | Anti-Mouse GUCY2C monoclonal antibody | Mouse |
| GM-Tg-cynog-T97947-Ab-1/ GM-Tg-cynog-T97947-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GUCY2C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T97947-Ab-1/ GM-Tg-felg-T97947-Ab-2 | Anti-Feline GUCY2C monoclonal antibody | Feline |
| GM-Tg-cang-T97947-Ab-1/ GM-Tg-cang-T97947-Ab-2 | Anti-Canine GUCY2C monoclonal antibody | Canine |
| GM-Tg-bovg-T97947-Ab-1/ GM-Tg-bovg-T97947-Ab-2 | Anti-Bovine GUCY2C monoclonal antibody | Bovine |
| GM-Tg-equg-T97947-Ab-1/ GM-Tg-equg-T97947-Ab-2 | Anti-Equine GUCY2C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T97947-Ab-1/ GM-Tg-hg-T97947-Ab-2; GM-Tg-rg-T97947-Ab-1/ GM-Tg-rg-T97947-Ab-2; GM-Tg-mg-T97947-Ab-1/ GM-Tg-mg-T97947-Ab-2; GM-Tg-cynog-T97947-Ab-1/ GM-Tg-cynog-T97947-Ab-2; GM-Tg-felg-T97947-Ab-1/ GM-Tg-felg-T97947-Ab-2; GM-Tg-cang-T97947-Ab-1/ GM-Tg-cang-T97947-Ab-2; GM-Tg-bovg-T97947-Ab-1/ GM-Tg-bovg-T97947-Ab-2; GM-Tg-equg-T97947-Ab-1/ GM-Tg-equg-T97947-Ab-2 |
| Products Name | Anti-GUCY2C monoclonal antibody |
| Format | mab |
| Target Name | GUCY2C |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GUCY2C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-272 | Pre-Made Indusatumab biosimilar, Whole mAb ADC, Anti-GUCY2C Antibody: Anti-DIAR6/GC-C/GUC2C/MECILIL/STAR therapeutic antibody |
| Biosimilar | GMP-Bios-INN-866 | Pre-Made Indusatumab Vedotin Biosimilar, Whole Mab Adc, Anti-Gucy2C Antibody: Anti-DIAR6/GC-C/GUC2C/MECILIL/STAR therapeutic antibody Drug Conjugate |
| Target Antigen | Products Developing | Multi-species GUC2C/ GUCY2C/ DIAR6 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T97947 |
| Target Name | GUCY2C |
| Gene ID | 2984,14917,25711,699191,486671,101095109,282244,100063810 |
| Gene Symbol and Synonyms | DIAR6,GC-C,GCC,GUC2C,GUCY2C,HSER,MECIL,MUCIL,STAR |
| Uniprot Accession | P25092,P23897 |
| Uniprot Entry Name | GUC2C_HUMAN,GUC2C_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000070019 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: GUCY2C, gene name: GUCY2C, also named as DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR. This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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