Anti-ATS5/ ADAMTS5/ ADAM-TS 11 functional antibody
Anti-ATS5/ ADAMTS5/ ADAM-TS 11 functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T98896-Ab-1/ GM-Tg-hg-T98896-Ab-2 | Anti-Human ADAMTS5 monoclonal antibody | Human |
GM-Tg-rg-T98896-Ab-1/ GM-Tg-rg-T98896-Ab-2 | Anti-Rat ADAMTS5 monoclonal antibody | Rat |
GM-Tg-mg-T98896-Ab-1/ GM-Tg-mg-T98896-Ab-2 | Anti-Mouse ADAMTS5 monoclonal antibody | Mouse |
GM-Tg-cynog-T98896-Ab-1/ GM-Tg-cynog-T98896-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADAMTS5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T98896-Ab-1/ GM-Tg-felg-T98896-Ab-2 | Anti-Feline ADAMTS5 monoclonal antibody | Feline |
GM-Tg-cang-T98896-Ab-1/ GM-Tg-cang-T98896-Ab-2 | Anti-Canine ADAMTS5 monoclonal antibody | Canine |
GM-Tg-bovg-T98896-Ab-1/ GM-Tg-bovg-T98896-Ab-2 | Anti-Bovine ADAMTS5 monoclonal antibody | Bovine |
GM-Tg-equg-T98896-Ab-1/ GM-Tg-equg-T98896-Ab-2 | Anti-Equine ADAMTS5 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T98896-Ab-1/ GM-Tg-hg-T98896-Ab-2; GM-Tg-rg-T98896-Ab-1/ GM-Tg-rg-T98896-Ab-2; GM-Tg-mg-T98896-Ab-1/ GM-Tg-mg-T98896-Ab-2; GM-Tg-cynog-T98896-Ab-1/ GM-Tg-cynog-T98896-Ab-2; GM-Tg-felg-T98896-Ab-1/ GM-Tg-felg-T98896-Ab-2; GM-Tg-cang-T98896-Ab-1/ GM-Tg-cang-T98896-Ab-2; GM-Tg-bovg-T98896-Ab-1/ GM-Tg-bovg-T98896-Ab-2; GM-Tg-equg-T98896-Ab-1/ GM-Tg-equg-T98896-Ab-2 |
Products Name | Anti-ADAMTS5 monoclonal antibody |
Format | mab |
Target Name | ADAMTS5 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-ADAMTS5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T98896-Ag-1 | Recombinant multi-species ATS5/ ADAMTS5/ ADAM-TS 11 protein |
Target information
Target ID | GM-T98896 |
Target Name | ADAMTS5 |
Gene ID | 11096,23794,304135,707672,487713,101085063,286805,100066005 |
Gene Symbol and Synonyms | 9530092O11Rik,ADAM-TS 11,ADAM-TS 5,ADAM-TS5,ADAMTS-11,ADAMTS-5,ADAMTS1,ADAMTS11,ADAMTS5,ADMP-2,ASMP-2 |
Uniprot Accession | Q9UNA0,Q9TT92 |
Uniprot Entry Name | ATS5_HUMAN,ATS5_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000154736 |
Target Classification | N/A |
The target: ADAMTS5, gene name: ADAMTS5, also named as ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.