Dog/Canine lactoferrin antibody and antigen (recombinant protein)

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Diagnostic anti-Dog/Canine lactoferrin antibodies pairs and antigen for animal health (animal Dog/Canine Intestinal Health) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Validation Data

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Target/Biomarker Information

Canine lactoferrin, a pivotal component of the immune system in dogs, is a multifunctional glycoprotein that belongs to the transferrin family, known for its strong iron-binding capacity. This protein plays a significant role in various physiological and protective functions in canines, paralleling its functions in other species but tailored to the specific needs and health challenges of dogs. Lactoferrin is found in several bodily secretions, including saliva, tears, milk, and mucosal secretions, acting as a first line of defense against pathogens.

Antimicrobial Activity: Lactoferrin exhibits potent antimicrobial properties against a broad spectrum of microorganisms, including bacteria, viruses, fungi, and parasites. Its mechanism of action includes iron sequestration, which starves pathogens of the essential iron needed for their growth, and direct interaction with microbial membranes, which can disrupt their structure and function. In dogs, this translates to a critical role in preventing infections and supporting the body's innate immunity.

Immune Regulation: Beyond its antimicrobial functions, canine lactoferrin is also involved in modulating the immune response. It can enhance the activity of immune cells, such as neutrophils, macrophages, and lymphocytes, thereby bolstering the dog's immune defense against pathogens. Additionally, lactoferrin has anti-inflammatory properties, helping to control inflammation and prevent damage to tissues during infections or inflammatory diseases. This is particularly beneficial in managing chronic inflammatory conditions in dogs, such as allergic dermatitis or inflammatory bowel disease.

Promotion of Gut Health: Lactoferrin supports intestinal health by promoting the growth of beneficial gut flora and enhancing the barrier function of the intestinal lining. This is crucial for the absorption of nutrients and the prevention of pathogen invasion through the gut. For puppies, lactoferrin present in the mother's milk is vital for developing a healthy gut microbiome and immune system. In adult dogs, maintaining optimal gut health contributes to overall well-being and disease resistance.

Iron Metabolism and Antioxidant Activity: By binding iron, lactoferrin regulates its availability in the body, which is essential for various physiological processes, including oxygen transport and cellular respiration, while also limiting iron availability to pathogens. Lactoferrin's antioxidant properties further protect cells from oxidative stress, contributing to cellular health and longevity.

Therapeutic Potential: Given its broad-spectrum antimicrobial, immune-modulating, and anti-inflammatory properties, lactoferrin has potential therapeutic applications in veterinary medicine. It can be considered for supplementation in dogs with various infectious or inflammatory conditions, as well as for promoting overall health and resilience against diseases. Research into canine-specific benefits of lactoferrin supplementation is ongoing, with promising implications for enhancing disease treatment and prevention strategies in dogs.

In summary, canine lactoferrin is a critical component of the dog's natural defenses, offering protection against pathogens, supporting immune regulation, and contributing to gut health and systemic well-being. Its wide-ranging benefits underscore the importance of lactoferrin in canine health, with potential applications in dietary supplementation and therapeutic interventions aimed at bolstering the health and immunity of dogs.

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