Feline α-synuclein antibody and antigen (recombinant protein)

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Diagnostic anti-Feline α-synuclein antibodies pairs and antigen for animal health (animal Cat/Feline Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Target/Biomarker Information

Feline α-synuclein, a molecular counterpart to its human homologue, emerges as a captivating figure in the intricate tapestry of the feline nervous system. At its core, this protein is an intrinsically disordered marvel, defying conventional structural classifications. Structurally, it mirrors a "Janus-faced" molecule, featuring an amphipathic N-terminal segment, a central hydrophobic region, and a negatively charged C-terminal tail. This unique structural makeup hints at its versatile roles within the neuronal realm.

Feline α-synuclein's primary abode lies within the central nervous system of cats, where it assumes an array of pivotal roles. Among its most notable functions is its influence on synaptic vesicle dynamics. It dynamically associates with synaptic vesicles, orchestrating their trafficking and modulating neurotransmitter release. This role positions Feline α-synuclein as a key conductor in the finely tuned orchestra of synaptic transmission.

Beyond the mechanics of neurotransmission, Feline α-synuclein wields influence over synaptic plasticity, the cornerstone of learning and memory. Its presence regulates synaptic strength and orchestrates the molecular cascades that underpin adaptive changes in neural circuits. In this capacity, Feline α-synuclein emerges as a molecular architect of cognitive processes in cats.

Yet, the intrigue surrounding Feline α-synuclein deepens when we delve into its propensity to aggregate, paralleling its human counterpart. Much like in humans, Feline α-synuclein can undergo conformational shifts leading to the formation of insoluble protein aggregates, Lewy bodies. These aggregates are central to the pathogenesis of neurodegenerative disorders, particularly in aging cats. Understanding the triggers and dynamics of this transition into aggregation-prone states is a focal point of research, as it holds the key to unraveling the mysteries of these debilitating diseases.

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