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Neurofilaments are cytoskeletal components of neurons that are particularly abundant in axons. Their functions include provision of structural support and maintaining size, shape, and caliber of the axons (1). Neurofilaments belong to the intermediate filaments family, and the triplet comprises three subunits; neurofilament light chain (NF-L), neurofilament medium (NF-M) and neurofilament heavy (NF-H). The nomenclature-light (~68 kDa), -medium (~145 kDa),- and heavy (~200 kDa) refers to the molecular weight of the filaments (2, 3). Following axonal damage in the central nervous system (CNS), neurofilament proteins released into cerebrospinal fluid (CSF) provide an indication of axonal damage and neuronal death. The most extensively subtype studied in this context is NF-L. Given that neurofilaments are found in the cytoplasm of neurons, all diseases that lead to neuronal and axonal damage can increase the CSF-levels of these proteins. In animal studies, NF-L levels have been used as a marker of axonal damage for decades . In humans, neurofilaments were used as markers of neuronal damage in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD).

Genemedi produces core diagnostic ingredients for test of Neuropathy and related syndrome. GeneMedi offers paired diagnostics grade neurofilament light chain (NFL) antibodies (monoclonal antibody, mab) and neurofilament light chain (NFL) antigens for Neuropathy rapid test kit of neurofilament light chain (NFL) testing in positive control, ELISA test,Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

All the antibodies and antigens for Neuropathy test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibodies can act as a capture antibody and detection antibody. The antigens can be used for antibodies rapid test of Neuropathy.

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With the COVID-19 outbreak in the world, many flights have been cancelled. In order for the customer to receive the goods properly, we use the FedEx Customized Freight (FCF) of Fedex which demands a higher fee. If the delivery fee is more expensive in your area, we will contact you by mail.

Catalog No. Size Price(In USD) Qty (Quantity) Sum(In USD)
GMP-NFL-Ag Size:1mg 1176
GMP-NFL-Ag Size:10mg 18963
GMP-NFL-Ag Size:100mg 48860
GMP-NFL-Ag ≥100mg Inquiry
Shipping Cost: 760.00
Total:



Description


Cat No. GMP-NFL-Ag
Product Name Recombinant neurofilament light chain (NFL, His Tag)
Expression platform E.coli
IsotypesRecombinant Antigen
Bioactivity validationneurofilament light chain (NFL) Antibody Binding, Immunogen in Sandwich ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
TagHis
Products descriptionRecombinant neurofilament light chain (NFL, His Tag) is produced by E.coli expression system with a 6His tag.
SpecicsNA
PurityPurity: ≥95% (SDS-PAGE)
Application positive control,ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.