Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus antibody and antigen (recombinant protein)

Diagnostic anti-Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus antibodies pairs and antigen for animal health (animal Cat/Feline infectious disease Feline infectious peritonitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P025-Ag01 Recombinant Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus protein $3090.00
GMP-VT-P025-Ab01 Anti-Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P025-Ab02 Anti-Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P025-Ag01
Product Name Recombinant Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus protein
Pathogen Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus level test of animal Cat/Feline infectious disease with Feline infectious peritonitis.
Tag His
Product description Recombinant Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P025-Ab01,GMP-VT-P025-Ab02
Pathogen Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus
Product Name Anti-Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus antibodies in Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus level test of animal Cat/Feline infectious disease with Feline infectious peritonitis.
Product description Anti-Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Coronavirus(FCoV)/Feline Infectious Peritonitis Virus antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Pathogen


    Feline Coronavirus (FCoV) or Feline Infectious Peritonitis Virus is a viral pathogen that belongs to the family Coronaviridae. This family of viruses consists of enveloped RNA viruses, and there are several different types of coronaviruses that can infect both humans and animals. FCoV is a member of the genus Alphacoronavirus, which infects a variety of mammalian species, with domestic cats being one of the primary hosts.

    FCoV has a positive-sense single-stranded RNA genome that encodes several structural and non-structural proteins. The replicase genes are responsible for viral replication and are encoded by open reading frames 1a and 1b. These genes code for proteins involved in RNA synthesis, such as RNA-dependent RNA polymerase. The spike (S) protein is a major structural protein of FCoV and is responsible for viral entry into host cells. The S protein is also responsible for inducing neutralizing antibodies in the host, which can help protect against future infections. Other non-structural proteins include those involved in RNA transcription, processing, and modification.

    FCoV primarily infects domestic cats and some wild feline species, leading to two distinct diseases: feline enteric coronavirus (FECV) and feline infectious peritonitis (FIP). FECV typically causes mild gastrointestinal symptoms, such as diarrhea and vomiting, and is often asymptomatic. In contrast, FIP is a severe and often fatal systemic disease characterized by widespread inflammation and damage to multiple organs, including the liver, kidneys, and lungs. Upon infection, FCoV initially infects cells in the intestinal tract, where it replicates and spreads to other tissues through the bloodstream. In some cats, the immune response to the virus is ineffective, leading to the development of FIP.

    Various diagnostic methods are available for FCoV detection, including serology, antigen testing, and nucleic acid testing (NAT). NAT methods involve reverse transcriptase polymerase chain reaction (RT-PCR) and real-time PCR tests, which target specific genes such as the S protein gene and the 7b gene. These tests are highly sensitive and specific and can detect the virus in both fecal samples and tissue samples. Enzyme-linked immunosorbent assay (ELISA) can also be used for serological diagnosis, which detects antibodies against the virus in blood samples.

    Prevention and treatment of FCoV infections in cats can be challenging. There is currently no vaccine available for FCoV, although research is ongoing to develop one. Management strategies for cats infected with FCoV include maintaining good hygiene practices, limiting contact with other cats, and providing supportive care for cats with FIP. Treatment for FIP is largely supportive and includes anti-inflammatory drugs, immunosuppressive drugs, and palliative care measures.

    In conclusion, Feline Coronavirus (FCoV) or Feline Infectious Peritonitis Virus is a viral pathogen that primarily infects domestic cats and can lead to two distinct diseases: feline enteric coronavirus (FECV) and feline infectious peritonitis (FIP). Various diagnostic methods are available for FCoV detection, and there is currently no vaccine available for prevention. Prevention and treatment of FCoV infections in cats require proper management strategies and supportive care.



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