Chlamydia avium antibody and antigen (recombinant protein)

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Diagnostic anti-Chlamydia avium antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Avian chlamydiosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P165-Ag01	Recombinant Chlamydia avium protein	$3090.00
GMP-VT-P165-Ab01	Anti-Chlamydia avium mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P165-Ab02	Anti-Chlamydia avium mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P165-Ag01
Product Name	Recombinant Chlamydia avium protein
Pathogen	Chlamydia avium
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Chlamydia avium antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Chlamydia avium level test of animal Avian/Bird/Poultry infectious disease with Avian chlamydiosis.
Tag	His
Product description	Recombinant Chlamydia avium proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P165-Ab01,GMP-VT-P165-Ab02
Pathogen	Chlamydia avium
Product Name	Anti-Chlamydia avium mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Chlamydia avium antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Chlamydia avium antibodies in Chlamydia avium level test of animal Avian/Bird/Poultry infectious disease with Avian chlamydiosis.
Product description	Anti-Chlamydia avium mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Chlamydia avium antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Chlamydia avium: A Comprehensive Overview

Introduction

Chlamydia avium, a member of the family Chlamydiaceae, is an obligate intracellular bacterium with a distinct preference for avian hosts. This pathogenic microorganism has garnered significant attention due to its impact on avian species, particularly psittacine birds (such as parrots, macaws, and cockatiels) and pigeons. Infection with Chlamydia avium can lead to a range of clinical manifestations, from ocular conditions like conjunctivitis to respiratory tract infections and systemic diseases. This comprehensive overview aims to provide a detailed insight into the taxonomy, structure, hosts, associated diseases, and diagnostic methods for Chlamydia avium.

Taxonomy and Classification

Chlamydia avium falls under the phylum Chlamydiae, class Chlamydiae, order Chlamydiales, family Chlamydiaceae, and genus Chlamydia. As a prokaryotic bacterium, it exhibits unique characteristics within the Chlamydiaceae family, distinguishing it from other Chlamydia species.

Genomic Landscape and Structural Components

The genome of Chlamydia avium harbors an array of genes pivotal for its pathogenicity and intracellular survival. Among these, the Major Outer Membrane Protein (MOMP) gene stands out as a significant determinant of its structure and host-cell interactions. The MOMP protein, an integral component of the outer membrane, not only plays a critical role in maintaining structural integrity but also acts as a crucial immunogenic factor.

Host Range and Disease Spectrum

Chlamydia avium displays a notable tropism for avian hosts, primarily targeting psittacine birds and pigeons. Upon infection, the pathogen may manifest in various clinical conditions. Conjunctivitis, characterized by ocular inflammation, is a common presentation, often leading to clinical signs like ocular discharge and reddening. Respiratory tract infections, involving the trachea and air sacs, have been documented in affected birds. In severe cases, systemic infections can occur, potentially leading to a range of systemic symptoms and organ involvement.

Diagnostic Approaches

Accurate and timely diagnosis of Chlamydia avium infections is paramount for effective management and prevention of transmission. Nucleic acid-based diagnostic methods serve as the cornerstone for detection. These techniques target specific genetic loci within the pathogen's genome, offering high specificity and sensitivity. The outer membrane protein A gene (ompA) is a frequently utilized target due to its conserved nature and immunogenic properties. Additionally, the 16S ribosomal RNA gene, exhibiting high sequence conservation among Chlamydia species, is another key target in molecular diagnostic assays. Complementing these, the inclusion membrane protein A gene (IncA) also finds application in molecular diagnostic tests, further enhancing the accuracy of detection.

Conclusion

Chlamydia avium, as an avian-specific pathogen, underscores the significance of understanding host-pathogen interactions in the context of zoonotic diseases. Its unique genomic and structural features, coupled with a distinct preference for avian hosts, position Chlamydia avium as a notable entity in the field of avian medicine. Accurate diagnosis, leveraging nucleic acid-based techniques targeting specific genetic markers, plays a pivotal role in effective disease management and prevention. Continued research into the molecular and clinical aspects of Chlamydia avium is essential for advancing our understanding of this pathogen and for the development of targeted therapeutic interventions.

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