Avian Nephrits Virus / Avastrovirus 2 antibody and antigen (recombinant protein)

Diagnostic anti-Avian Nephrits Virus / Avastrovirus 2 antibodies pairs and antigen for animal health (animal Chicken infectious disease avian nephritis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Avian/Bird/Poultry disease testing products collection >>


Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P199-Ag01 Recombinant Avian Nephrits Virus / Avastrovirus 2 protein $3090.00
GMP-VT-P199-Ab01 Anti-Avian Nephrits Virus / Avastrovirus 2 mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P199-Ab02 Anti-Avian Nephrits Virus / Avastrovirus 2 mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P199-Ag01
Product Name Recombinant Avian Nephrits Virus / Avastrovirus 2 protein
Pathogen Avian Nephrits Virus / Avastrovirus 2
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Avian Nephrits Virus / Avastrovirus 2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Avian Nephrits Virus / Avastrovirus 2 level test of animal Chicken infectious disease with avian nephritis.
Tag His
Product description Recombinant Avian Nephrits Virus / Avastrovirus 2 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P199-Ab01,GMP-VT-P199-Ab02
Pathogen Avian Nephrits Virus / Avastrovirus 2
Product Name Anti-Avian Nephrits Virus / Avastrovirus 2 mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Avian Nephrits Virus / Avastrovirus 2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Nephrits Virus / Avastrovirus 2 antibodies in Avian Nephrits Virus / Avastrovirus 2 level test of animal Chicken infectious disease with avian nephritis.
Product description Anti-Avian Nephrits Virus / Avastrovirus 2 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Nephrits Virus / Avastrovirus 2 antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Pathogen


    Avian Nephritis Virus is an RNA virus that primarily infects chickens. This virus belongs to the Astroviridae family and is classified as a non-enveloped, positive-sense single-stranded RNA virus. The genome of Avian Nephritis Virus consists of a single-stranded RNA molecule of approximately 7.4 kilobases in length. The genome of the virus is organized into three open reading frames (ORFs), which encode the structural protein, capsid protein, and the non-structural protein, respectively.

    The capsid protein of Avian Nephritis Virus plays a crucial role in determining the host range and tissue tropism of the virus. It is responsible for protecting the viral RNA genome from degradation and facilitating viral entry into host cells. The capsid protein of Avian Nephritis Virus forms the outer shell of the virus, which is composed of 32 well-ordered trimeric spikes that protrude from the viral surface. These spikes are involved in attaching the virus to the host cell receptor and initiating viral entry into the host cell.

    Avian Nephritis Virus primarily infects domestic chickens and is responsible for causing several diseases, including avian nephritis, nephrosis-nephritis syndrome, and malabsorption syndrome. Avian nephritis is a kidney disease that affects broiler chickens and can cause acute mortality in young birds. The major clinical signs of avian nephritis include increased water intake, diuresis, lethargy, dehydration, and weight loss. Nephrosis-nephritis syndrome is characterized by a combination of renal disease, immunosuppression, and enteritis, which can lead to severe mortality in chickens. Malabsorption syndrome is another disease caused by this virus, where infected chickens have impaired nutrient absorption leading to growth retardation and mortality.

    The pathogenesis of Avian Nephritis Virus in chickens is not entirely understood, although studies suggest that the virus infects renal tubular epithelial cells and induces a severe inflammatory response, leading to the destruction of the renal tissues. The virus may also cause immunosuppression by disrupting T-cell function and inhibiting the production of cytokines.

    Diagnostic methods for Avian Nephritis Virus include virus isolation, serological assays, and nucleic acid-based assays. Virus isolation involves culturing the virus in specific cell lines or embryonated eggs and observing cytopathic effects or hemagglutination. Serological assays detect specific antibodies against Avian Nephritis Virus in serum samples using techniques like ELISA or western blotting. Nucleic acid-based assays detect viral RNA using techniques such as RT-PCR, targeting genes like ORF1b, ORF2, or the capsid protein gene.

    In conclusion, Avian Nephritis Virus (Avastrovirus 2) is a highly infectious pathogen that primarily affects domestic chickens and causes several diseases like avian nephritis, nephrosis-nephritis syndrome, and malabsorption syndrome. The disease has significant economic implications for the poultry industry worldwide. Therefore, early and accurate diagnosis of this virus is highly important for effective disease control and prevention.



    About GDU


    GDU

    GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.