Bordetella avium antibody and antigen (recombinant protein)

Diagnostic anti-Bordetella avium antibodies pairs and antigen for animal health (animal Turkey infectious disease bordetellosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Avian/Bird/Poultry disease testing products collection >>


Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P201-Ag01 Recombinant Bordetella avium protein $3090.00
GMP-VT-P201-Ab01 Anti-Bordetella avium mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P201-Ab02 Anti-Bordetella avium mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P201-Ag01
Product Name Recombinant Bordetella avium protein
Pathogen Bordetella avium
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Bordetella avium antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Bordetella avium level test of animal Turkey infectious disease with bordetellosis.
Tag His
Product description Recombinant Bordetella avium proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P201-Ab01,GMP-VT-P201-Ab02
Pathogen Bordetella avium
Product Name Anti-Bordetella avium mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Bordetella avium antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bordetella avium antibodies in Bordetella avium level test of animal Turkey infectious disease with bordetellosis.
Product description Anti-Bordetella avium mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bordetella avium antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen


    Bordetella avium is a gram-negative bacterium that belongs to the genus Bordetella. This bacterium is known to cause respiratory disease in birds, including poultry and wild birds. Avian bordetellosis is a highly contagious bacterial disease caused by Bordetella avium, which is characterized by respiratory symptoms such as coughing, sneezing, and nasal discharge.

    Bordetella avium is a rod-shaped bacterium that is typically 1-3 micrometers in length and 0.2-0.5 micrometers in diameter. It has a relatively simple cell structure, consisting of a cell membrane, cytoplasm, and nucleoid region. The cell wall of Bordetella avium is made up of peptidoglycan, lipopolysaccharides (LPS), and several other proteins.

    The virulence of Bordetella avium is regulated by the bvgA gene, which encodes for a transcriptional activator that controls the expression of virulence factors. This gene is part of the BvgAS two-component system, which enables the bacterium to sense changes in its environment and respond accordingly. When the bacterium encounters specific environmental signals, such as temperature and nutrient availability, the BvgAS system activates the expression of virulence genes, including the filamentous hemagglutinin (FHA) protein.

    FHA is a major virulence factor of Bordetella avium, which plays a crucial role in attachment to host cells. This protein is composed of several subunits, including FhaB, FhaC, and FhaD. FhaB is the largest subunit, which contains a receptor-binding domain that allows the bacterium to attach to specific receptors on the surface of host cells. FhaC and FhaD are minor subunits that form a pore-like structure in the bacterial outer membrane, which enables FHA to be transported to the cell surface.

    Bordetella avium primarily infects birds, including wild and domesticated poultry. The disease can spread rapidly through bird populations, causing significant economic losses in the poultry industry. Avian bordetellosis is characterized by respiratory symptoms such as coughing, sneezing, and nasal discharge. Affected birds may also experience decreased egg production and increased mortality rates.

    Diagnostic methods for Bordetella avium include bacterial culture, polymerase chain reaction (PCR), and serology. Bacterial culture involves the isolation and identification of the bacterium from infected tissue samples. PCR targets the bvgA gene, which is specific to Bordetella avium. Serology detects antibodies against the FHA protein, which can be used to confirm exposure to the bacterium. Nucleic acid-based diagnostic methods, such as PCR, are particularly useful for detecting low levels of the bacterium in asymptomatic carriers.

    In conclusion, Bordetella avium is a gram-negative bacterium that causes respiratory disease in birds. This bacterium is highly contagious and can cause significant economic losses in the poultry industry. Understanding the structure and virulence factors of Bordetella avium is essential for developing effective control strategies. Diagnostic methods such as bacterial culture, PCR, and serology can aid in the detection and identification of this pathogen.



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