Rift Valley fever Virus antibody and antigen (recombinant protein)

Diagnostic anti-Rift Valley fever Virus antibodies pairs and antigen for animal health (animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish infectious disease Rift Valley fever) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P256-Ag01 Recombinant Rift Valley fever Virus protein $3090.00
GMP-VT-P256-Ab01 Anti-Rift Valley fever Virus mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P256-Ab02 Anti-Rift Valley fever Virus mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P256-Ag01
Product Name Recombinant Rift Valley fever Virus protein
Pathogen Rift Valley fever Virus
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Rift Valley fever Virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Rift Valley fever Virus level test of animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish infectious disease with Rift Valley fever.
Tag His
Product description Recombinant Rift Valley fever Virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P256-Ab01,GMP-VT-P256-Ab02
Pathogen Rift Valley fever Virus
Product Name Anti-Rift Valley fever Virus mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Rift Valley fever Virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rift Valley fever Virus antibodies in Rift Valley fever Virus level test of animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish infectious disease with Rift Valley fever.
Product description Anti-Rift Valley fever Virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rift Valley fever Virus antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Pathogen


    Rift Valley fever virus (RVFV) is a zoonotic virus that causes outbreaks of disease in domesticated animals and humans. It was first identified in the Rift Valley of Kenya in 1931, and since then, has spread throughout East and Southern Africa, as well as parts of the Middle East.

    RVFV is classified as a single-stranded RNA virus belonging to the Phlebovirus genus of the family Phenuiviridae. Its genome consists of three segments: small (S), medium (M), and large (L). The S-segment (~1.7kb) encodes for the viral nucleocapsid protein (N), which encapsidates the viral RNA, as well as a nonstructural protein (NSs) that plays a role in immune evasion. The M-segment (~4.8kb) encodes for the surface glycoproteins (Gn/Gc) responsible for receptor binding and entry into host cells, as well as a nonstructural protein (NSm) that is involved in viral assembly and budding. The L-segment (~6.3kb) encodes for the RNA-dependent RNA polymerase, which is essential for viral replication.

    RVFV primarily infects domesticated animals such as cattle, sheep, and goats through mosquito bites, ingestion of contaminated feed or water, or exposure to infected animal tissue or bodily fluids. The virus can also infect wild animals, including camels and buffalo. Once infected, the animals develop a range of clinical signs, including fever, anorexia, depression, and in severe cases, hemorrhagic fever, abortion, or death. In livestock, these outbreaks can cause significant economic losses due to death and decreased productivity.

    Humans can become infected with RVFV through contact with infected animal tissue or bodily fluids or through mosquito bites. Once infected, the disease can manifest in different ways, from a mild febrile illness to a severe hemorrhagic fever or encephalitis. The incubation period of RVFV ranges from 2 to 6 days, after which the symptoms appear. The most common symptoms of RVFV infection include fever, headache, muscle pain, and weakness. In 1% of cases, the infection can progress to severe disease, including retinitis, meningoencephalitis, and hemorrhagic fever, which can be fatal in up to 50% of cases.

    The diagnosis of RVFV is based on clinical signs and symptoms, as well as laboratory tests. Nucleic acid amplification techniques like RT-PCR targeting specific regions of the S-segment or N-gene are used to detect the viral RNA in blood, serum, or tissue samples. Other methods, like enzyme-linked immunosorbent assays (ELISAs) and neutralization assays, detect antibodies to RVFV in blood samples. Proteins targeted by these methods may include the viral surface glycoprotein, nucleocapsid protein, or other viral antigens.

    There is no specific treatment for RVFV infection, and management of the disease is mainly supportive. Patients with severe disease may require hospitalization, with treatment focused on symptom relief and preventing complications such as dehydration. Prevention measures include mosquito control, vaccination of domesticated animals, and public health education.

    In conclusion, Rift Valley fever virus is a zoonotic virus that causes outbreaks of disease in domesticated animals and humans. It is a single-stranded RNA virus that primarily infects domesticated animals, with transmission to humans occurring through mosquito bites or contact with infected animal tissue or bodily fluids. Although most human infections with RVFV are self-limiting, severe cases can be fatal and cause significant public health and economic impacts. The diagnosis of RVFV relies on laboratory testing, and prevention measures include mosquito control and vaccination of animals.



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